ZEB2 Monoclonal Antibody (OTI3D8), TrueMAB™, OriGene

Catalog No.	Quantity
50-167-9114	100 μL

Catalog No. 50-167-9114 Supplier OriGene Supplier No. TA802110

Description

Mouse Monoclonal Antibody

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

Specifications

• Antigen: ZEB2
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI3D8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ZEB2
• Gene Accession No.: O60315
• Gene Alias: HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B
• Gene Symbols: ZEB2
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-350 of human ZEB2 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9839
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1