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Invitrogen™ ZEB2 Polyclonal Antibody
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Catalog No. PIPA520980 Shop All Thermo Scientific Products
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PIPA520980 100 μg
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Catalog No. PIPA520980 Supplier Invitrogen™ Supplier No. PA520980
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Description

Rabbit Polyclonal Antibody

Due to post-translational modifications, ZEB2 migrates at ~180kDa in SDS-PAGE. A suggested positive control is Jurkat cell lysate. PA5-20980 can be used with blocking peptide PEP-1094.

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZEB2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Zeb2
Gene Accession No. O60315, Q9R0G7
Gene Alias 9130203F04Rik; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; SIP1; SIP-1; SMAD interacting protein 1; smad-interacting protein 1; SMADIP1; Zeb2; ZFHX1B; Zfx1b; Zfxh1b; zinc finger E-box binding homeobox 2; zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; zinc finger homeobox protein 1b
Gene Symbols Zeb2
Host Species Rabbit
Immunogen An 18 amino acid peptide near the carboxy terminus of human ZEB2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24136, 311071, 9839
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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