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Invitrogen™ ZEB2 Polyclonal Antibody
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Catalog No. PIPA578302
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100 μL
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PIPA578302 100 μL
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Catalog No. PIPA578302 Supplier Invitrogen™ Supplier No. PA578302
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Description

Rabbit Polyclonal Antibody

Positive Control: MEF, A375, Neuro 2A, C8D30, Raw264.7, C2C12, rat brain Predicted Reactivity: Xenopus laevis (87%), Chicken (93%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZEB2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.42 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Zeb2
Gene Accession No. O60315, Q9R0G7
Gene Alias 9130203F04Rik; D130016B08Rik; HRIHFB2411; HSPC082; KIAA0569; SIP1; SIP-1; SMAD interacting protein 1; smad-interacting protein 1; SMADIP1; Zeb2; ZFHX1B; Zfx1b; Zfxh1b; zinc finger E-box binding homeobox 2; zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; zinc finger homeobox protein 1b
Gene Symbols Zeb2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human ZEB2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24136, 9839
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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