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Invitrogen™ Zenon™ Alexa Fluor™ Plus IgG Labeling Reagents

Catalog No. Z25615
Encompass_Preferred
Click to view available options
Label or Dye:
Alexa Fluor™ Plus 488
Alexa Fluor™ Plus 594
Alexa Fluor™ Plus 647
Species:
Human
Mouse
Color:
Far-red
Green
Red
Excitation/Emission:
494/519 nm
590/617 nm
650/671 nm

Zenon Alexa Fluor Plus Labeling Reagents provide rapid, scalable antibody labeling and give a bright fluorescence-based indication of antibody binding when analyzed by flow cytometry, fluorescence microscopy, or high-content screening.

Streamline therapeutic antibody discovery campaigns with Zenon Alexa Fluor Plus Labeling Reagents to screen for antibody binding. These reagents provide rapid, scalable antibody labeling and give a bright fluorescence-based indication of antibody binding when analyzed by flow cytometry, fluorescence microscopy, or high-content screening.

An effective cell-based screening model is critical for the success of therapeutic antibody discovery campaigns. This serves as an important filter in the early stages of drug development. Identifying antibodies with optimal binding profiles accelerates candidate selection and helps minimize false positives. The new Zenon Alexa Fluor Plus Labeling Reagents are prelabeled Fab fragments directed against the Fc portion of IgG antibodies. They are improved in three ways: superior pan-reactive Fab fragments, optimized bioconjugation, and next-generation fluorophores. These combine to provide superior signal to background, providing more confidence in screening results.

The Zenon Alexa Fluor Plus IgG Labeling Reagents contain sufficient material to label one to four 96-well plates, depending on the Zenon labeling reagent concentration used. Formation of the Fab–antibody complex occurs in less than 5 minutes. Only a small amount of starting material is needed, and the method is optimized for efficient labeling of antibodies in serum, ascites fluid, or hybridoma suspensions. The insights provided by these approaches have the potential to accelerate biotherapeutic lead generation and development.

Advantages of Zenon Alexa Fluor Plus IgG Labeling Reagents include:
Simplicity—No reagent purification is required
Accuracy—No wash steps or quenchers are needed, maximizing throughput
Speed—Labeled antibodies are typically ready to use in 5 minutes
Specificity—Dyes are designed for the specific detection of antibody binding

Preserve primary antibody function and affinity
Reactive dye labeling of primary antibodies can have unpredictable and undesirable outcomes. One of these is reduced binding affinity due to label addition in the binding pocket. The Zenon antibody labeling approach, which is targeted to the Fc tail, resolves this potential issue.

Try custom antibody conjugates
If the antibody conjugate you need is not available as one of our stocked products, we will prepare a custom antibody conjugate for you. Our custom conjugation service is efficient and confidential, and we stand by the quality of our work. We are ISO 9001:2000 certified.

TRUSTED_SUSTAINABILITY

Specifications

For Use With (Application) Antibody binding screening
Quantity 240 μL
Product Type Labeling Reagent
Species Human
Content And Storage Store in refrigerator (2–8°C) and protect from light.
Detection Method Fluorescence
Flow Cytometer Laser Lines 488
Target Human IgG Fc domain
Label or Dye Alexa Fluor™ Plus 488
Label Type Alexa Fluor
Color Green
Product Line Zenon™
Emission 519 nm
Excitation 494 nm
Labeling Target IgG
Excitation/Emission 494/519 nm
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