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  5. Tocris™ ZLD 1039

Tocris™ ZLD 1039

Catalog No. 584710
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Catalog No. Quantity
58-471-0 10 mg
58-475-0 50 mg
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Catalog No. 58-471-0 Supplier Tocris™ Supplier No. 5847/10
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Description

Potent and selective EZH2 inhibitor

ZLD 1039 is a potent and selective EZH2 inhibitor (IC50 = 5.6 nM). Displays selectivity for EZH2 over a panel of HMTs (inhibition less than 30% at 16 μM). Blocks H3K27 methylation in breast cancer cell lines. Induces tumor regression and metastasis in breast cancer xenograft-bearing mice. Reactivates silenced tumor suppressors in vivo. Orally bioavailable.

Specifications

Chemical Name or Material 3-[Ethyl(tetrahydro-2H-pyran-4-yl)amino]-N-[(2,3,5,6,7,8-hexahydro-1-methyl-3-oxo-4-isoquinolinyl)methyl]-2-methyl-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]benzamide
CAS 1826865-46-6
Quantity 10 mg
Molecular Formula C36H48N6O3
Purity 98%
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