ZNF451 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-4801	150 μL

Catalog No. 50-173-4801 Supplier Proteintech Group Inc Supplier No. 252281AP150UL

Description

Rabbit Polyclonal Antibody

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in maligt cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of maligt cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

Specifications

• Antigen: ZNF451
• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.31 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: ZNF451
• Gene Accession No.: Q9Y4E5
• Gene Alias: COASTER, KIAA0576, KIAA1702, zinc finger protein 451, ZNF451
• Gene Symbols: ZNF451
• Host Species: Rabbit
• Immunogen: ZNF451 Fusion Protein Ag18346
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 26036
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG