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Invitrogen™ ZNRF2 Polyclonal Antibody
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Catalog No. PIPA584890
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PIPA584890 100 μL
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Catalog No. PIPA584890 Supplier Invitrogen™ Supplier No. PA584890
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NSSSGPYGSQ DSVHSSPEDG GGGRDRPVGG SPGGPRLVIG SLPAHLSPHM FGGFKCPVCS KFVSSDEMDL HLVMCLTK Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 86%.

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZNRF2
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Znrf2
Gene Accession No. Q8NHG8
Gene Alias 1190002C14Rik; AU044205; D6Ertd365e; E3 ubiquitin-protein ligase ZNRF2; protein Ells2; RING finger protein 202; RING-type E3 ubiquitin transferase ZNRF2; RNF202; zinc and ring finger 1; zinc and ring finger 2; zinc and ring finger 2, E3 ubiquitin protein ligase; zinc finger/RING finger 2; zinc/RING finger protein 2; Znrf1; Znrf2
Gene Symbols Znrf2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ZNRF2. Recombinant protein control fragment (Product #RP-108596).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 223082
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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