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Invitrogen™ ZO-1 Recombinant Rabbit Monoclonal Antibody (HL1185)
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Catalog No. PIMA546951
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100 μL
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Catalog No. Quantity
PIMA546951 100 μL
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Catalog No. PIMA546951 Supplier Invitrogen™ Supplier No. MA546951
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Description

Rabbit Recombinant Monoclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial.

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
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Specifications

Antigen ZO-1
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone HL1185
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene TJP1
Gene Accession No. P39447, Q07157
Gene Alias DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Gene Symbols TJP1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human ZO-1. The exact sequence is proprietary.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21872, 292994, 7082
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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