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Invitrogen™ ZO-1 Polyclonal Antibody

Catalog No. PI187430
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500 μL
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PI187430 500 μL
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Catalog No. PI187430 Supplier Invitrogen™ Supplier No. 187430
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Description

Rabbit Polyclonal Antibody

ZO-1 Polyclonal Antibody for ICC/IF, IHC (P)

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZO-1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.4
Gene TJP1
Gene Accession No. Q07157
Gene Alias DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Gene Symbols TJP1
Host Species Rabbit
Immunogen Peptide sequence from the N-terminal region of human ZO-1.
Purification Method Purified
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7082
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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