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Apexbio Technology LLC Zoniporide (hydrochloride) 241800-97-5 50mg
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Supplier:  Apexbio Technology LLC C348050

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Zoniporide (hydrochloride) (CAS 241800-97-5) is a potent and selective inhibitor of sodium-hydrogen exchanger isoform-1 (NHE-1) the primary regulator of intracellular pH in cardiac myocytes Zoniporide exhibits high selectivity for NHE-1 inhibiting the human isoform with an IC50 of 14 nM and demonstrating over 150-fold selectivity relative to other NHE isoforms In preclinical studies zoniporide reduced infarct size in isolated hearts and animal models of myocardial ischemia-reperfusion injury and attenuated NHE-1-mediated platelet swelling These properties make zoniporide a valuable tool for studying NHE-1 function in cardiovascular research and ischemia-reperfusion injury models

Catalog No. 50-000-89419


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