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Invitrogen™ Zyxin Monoclonal Antibody (CL2502)
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Catalog No. PIMA531367
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100 μL
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Catalog No. Quantity
PIMA531367 100 μL
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Catalog No. PIMA531367 Supplier Invitrogen™ Supplier No. MA531367
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Description

Mouse Monoclonal Antibody

Immunogen sequence: PAPKFSPVTP KFTPVASKFS PGAPGGSGSQ PNQKLGHPEA LSAGTGSPQP PSFTYAQQRE KPRVQEKQHP VPPPAQNQNQ VRSPGAPGPL TLKEVEELEQ LTQQLMQDME HPQRQNVAVN E Highest antigen sequence indentity to the following orthologs: Rat - 85%, Mouse - 84%.

Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Zyxin
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone CL2502
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ZYX
Gene Accession No. Q15942
Gene Alias 9530098H06Rik; ESP-2; HED-2; LOW QUALITY PROTEIN: zyxin; R75157; ZYX; Zyxin; zyxin-2
Gene Symbols ZYX
Host Species Mouse
Immunogen Recombinant protein fragment of Human ZYX (Product #RP-102436)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7791
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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