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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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Beta-Amyloid (1-11) (CAS 190436-05-6) is a synthetic peptide fragment derived from the N-terminus of the amyloid precursor protein comprising the amino acid sequence H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH This peptide represents a portion of the beta-amyloid (A ) sequence implicated in amyloidogenic pathways associated with neurodegenerative processes particularly Alzheimer s disease Beta-Amyloid (1-11) is utilized in research to investigate amyloid aggregation dynamics immunogenic epitope mapping within the A region and the biochemical properties of amyloidogenic peptides It serves as a molecular tool in studies examining the early stages of A processing clearance and interactions with cellular components
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D 4476 is a potent selective and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1 respectively Also acts as an ALK5 inhibitor with IC50 of 500 nM
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