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Nitrogenous bases covalently linked to a sugar with and without phosphate groups; used for synthesis, cell signaling, and as cofactors in enzymatic reactions; includes pyrimidine, purine, pyridine, flavin, pyrrolopyrimidine, and triazole varieties.
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Nicotinic acid mononucleotide (NaMN) is a nucleotide intermediate in the biosynthesis of NAD+. It is produced from nicotinic acid via phosphoribosyltransferase and serves as a substrate for adenylyltransferases involved in NAD+ metabolism. Supplied as a research-grade reagent for biochemical and enzymatic studies.
Intermediate in NAD+ biosynthesis and metabolism.
Substrate for adenylyltransferase and enzymatic assays.
High purity, typically ~98%.
Molecular weight 335.2 g·mol⁻1; formula C11H14NO9P.
Intended for research use only; not for human consumption.
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Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material which has long been of interest in understanding the mechanism of aging neurodegenerative diseases and carcinogenesis. The normal form of deoxyadenosine used in DNA synthesis and repair is 2'-deoxyadenosine where the hydroxyl group (-OH) is at the 2' position of its ribose sugar moiety. 5'-deoxyadenosine has its hydroxyl group at the 5' position of the ribose sugar. purity: 99%
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Oxidized low density lipoprotein (mouse) (Mouse ox-LDL) is an oxidized low density lipoprotein (LDL). It induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration, making it suitable for constructing an in vitro model of AS.
Induces atherosclerosis (AS)
Facilitates endothelial dysfunction
Accelerates VSMCs growth and migration
Can be used to construct an in vitro model of AS
Upregulates mRNA and protein expressions of long noncoding RNA TUG1 and receptor tyrosine kinase-like orphan receptor 2 (ROR2)
Promotes the proliferation of HA-VSMCs
Enhances migration and invasion abilities
Increases the expressions of metastasis-related proteins β-catenin and Vimentin in human aortic vascular smooth muscle cells
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Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC), is a nucleoside diphosphate that activates the adenosine 5'-triphosphate-sensitive K+ channel. It functions as an iron mobilizer by forming a complex with hepcidin, thereby inhibiting the hepcidin-ferroportin (FPN) interaction and modulating the IL-6/stat-3 pathway. This compound can ameliorate Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4 and is suitable for AI research.