Nucleosides and Analogues
Medchemexpress LLC Malvidin-3-O-arabinoside chloride | 28500-04-1 | 97.10% | 498.86 | 1 MG
Malvidin-3-O-arabinoside chloride ameliorates ethyl carbamate-induced oxidative damage by stimulating AMPK-mediated autophagy. It upregulates LAMP-1 expression, restores lysosomal acidity, strengthens lysosomal functions, and stimulates phosphorylation of AMP-activated protein kinase (AMPK).
- Upregulates LAMP-1 expression
- Restores lysosomal acidity
- Strengthens lysosomal functions
- Stimulates phosphorylation of AMP-activated protein kinase (AMPK)
- Inhibits excess ROS generation
- Enhances GSH level
- Enhances autophagy flux
- Up-regulates the LC3-II/LC3-I ratio
Cayman Chemical N6-benzoyl-2-DeoxyadenosIn 1g
A nucleoside building block; has been used in the synthesis of various oligonucleotides
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.9% | 269.26 | 50 G
2'-Deoxyadenosine monohydrate is an adenine nucleoside that inhibits glucose-stimulated insulin release. It also inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation, activates caspase-3, promotes apoptosis, and inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). Additionally, it inhibits the growth of various cells and exhibits an anticancer effect on colon cancer.
- Inhibits glucose-stimulated insulin release.
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation.
- Activates caspase-3 and promotes apoptosis.
- Inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH).
- Inhibits the growth of various cells.
- Has an anticancer effect on colon cancer.
Cayman Chemical 5-chloro-5-DeoxyadenosIn 10g
A nucleoside analog used as a substrate in the biosynthesis of the anticancer agent salinosporamide A
Medchemexpress LLC 2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate | 2483830-27-7 | 99.7% | 284.15 | 1 MG
2'-Deoxyadenosine monohydrate-13C10,15N5 hydrate | 2483830-27-7 | 99.7% | 284.15 | 1 MG
Chem-Impex International, Inc. N2-Isobutyryl-2'-deoxyguanosine | 68892-42-2 | MFCD00010060 | 25G
N2-Isobutyryl-2'-deoxyguanosine, 68892-42-2, MFCD00010060, 25G
Medchemexpress LLC 2'-Deoxyguanosine | 961-07-9 | 99.9% | 267.25 | 10 G
2'-Deoxyguanosine is a purine nucleoside with diverse biological activities, known to induce DNA division in mouse thymus cells and act as a potent cell division inhibitor in plant cells. It also demonstrates inhibitory effects on the clonal growth of HL-60 and K562 leukemia cells, with observed IC50 values of 50 and 80 μM, respectively. This compound typically appears as a solid, ranging from white to off-white in color.
- Endogenous metabolite
- Harmful if swallowed
- Causes skin irritation
- Causes serious eye irritation
- May cause respiratory irritation
Medchemexpress LLC 2'-Deoxyguanosine-d13 | 961-07-9 | 99.9% | 280.32 | 5 MG
2'-Deoxyguanosine-d13 is a deuterium-labeled version of 2'-Deoxyguanosine. It is intended for research use only and can be utilized as a tracer or as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. Deuteration, the incorporation of stable heavy isotopes of hydrogen into drug molecules, has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Sigma Aldrich Fine Chemicals Biosciences MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 25MG
MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 25MG
Medchemexpress LLC 2'-deoxyadenosine | 958-09-8 | MFCD00005754 | 251.24 g/mol | C10H13N5O3 | 500 MG
2'-deoxyadenosine is an adenine nucleoside supplied for research and analytical applications. The compound has been reported to inhibit glucose-stimulated insulin release, activate caspase-3 and promote apoptosis, and inhibit S-adenosyl-L-homocysteine hydrolase (SAHH).
- Adenine nucleoside for research applications.
- Modulates insulin-stimulated cAMP accumulation and insulin release.
- Promotes apoptosis via caspase-3 activation.
- Inhibits S-adenosyl-L-homocysteine hydrolase (SAHH).
- Available from suppliers in small research quantities (supplier pack indicated as 500 MG in provided row data).
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 25 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. This product is for research use only and not for sale to patients.
- Treatment results in rapid cell death for the vast majority of cancer cell lines tested, with IC50s between 0.7-2.9 μM.
- In A549 lung cancer cell-based mouse xenograft studies, it causes a decrease of the tumor growth rate, superior to that observed with 6-thioguanine treatment.
- It increases telomere dysfunction in tumor cells in vivo.