Organometallic Compounds
C)C(C)C | 250g | 254749461](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000162177.jpg-250.jpg)
eMolecules 6485-79-6 | Triisopropylsilane | Chem-Impex | MFCD00009657 | 158.360 | C9H22Si | 99.000 | CC(C)[SiH](C(C)C)C(C)C | 250g | 254749461
Triisopropylsilane | Chem-Impex | 6485-79-6 | MFCD00009657 | 158.360 | C9H22Si | 99.000 | CC(C)[SiH](C(C)C)C(C)C | 250g | 254749461
eMolecules 2363757-66-6 | Bis-sulfone-PEG8-NHS Ester | Broadpharm | MFCD30527389 | 1021.160 | C48H64N2O18S2 | 95.000 | Cc1ccc(cc1)S(=O)(=O)CC(CS(=O)(=O)c1ccc(C)cc1)C(=O)c1ccc(cc1)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 25mg | 573896527
Bis-sulfone-PEG8-NHS Ester | Broadpharm | 2363757-66-6 | MFCD30527389 | 1021.160 | C48H64N2O18S2 | 95.000 | Cc1ccc(cc1)S(=O)(=O)CC(CS(=O)(=O)c1ccc(C)cc1)C(=O)c1ccc(cc1)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 25mg | 573896527
Medchemexpress LLC PS-1145 | 431898-65-6 | 99.7% | 322.75 | 50 MG
PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM. It blocks TNFα-induced NF-κB activation in MM cells by inhibiting IκBα phosphorylation. Dexamethasone enhances the blockade of NF-κB activation by PS-1145.
- Blocks TNFα-induced NF-κB activation.
- Inhibits IκBα phosphorylation.
- Enhances blockade of NF-κB activation by Dexamethasone.
- Blocks protective effect of IL-6 against Dex-induced apoptosis.
- Inhibits TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
- Inhibits IL-6 secretion from bone marrow stromal cells.
- Inhibits proliferation of MM cells adherent to bone marrow stromal cells.
![Medchemexpress LLC 3-(quinolin-4-ylmethylamino)-N-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxamide | 728033-96-3 | MFCD11100358 | 98.3% | 443.44 g/mol | C22H16F3N3O2S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247328.png-250.jpg)
Medchemexpress LLC 3-(quinolin-4-ylmethylamino)-N-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxamide | 728033-96-3 | MFCD11100358 | 98.3% | 443.44 g/mol | C22H16F3N3O2S | 50 MG
Small-molecule tyrosine kinase inhibitor that targets Kit, KDR (VEGFR2), and CSF-1R (c-Fms), with reported IC50s of ~80 nM, 9 nM, and 15 nM, respectively. Supplied as a high-purity research compound (CAS 728033-96-3; formula C22H16F3N3O2S; MW 443.44 g/mol).
- Selective inhibition of Kit, KDR (VEGFR2), and CSF-1R at low nanomolar concentrations.
- Demonstrates antitumor activity in preclinical studies.
- Suitable for biochemical kinase assays and cell-based signaling studies.
- Provided as a high-purity compound for research applications.
- Defined molecular weight and formula for accurate dosing and calculations.
Medchemexpress LLC (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 2097971-11-2 | MFCD31656714 | 99.0% | 656.23 g/mol | C30H46ClN5O7S | 100 MG
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a VHL E3 ligase ligand-linker conjugate functionalized with a PEG3 amine, provided as the hydrochloride salt and intended for use as a building block in PROTAC and targeted protein degradation research.
- Hydrochloride salt supplied as a solid, light yellow to yellow.
- High reported purity (≈99%).
- Molecular weight ~656.23 g/mol (hydrochloride form).
- PEG3 amine functionalization enables linker conjugation to target ligands.
- Intended for use in medicinal chemistry and chemical biology applications.
eMolecules 52093-30-8 | Yttrium(III) trifluoromethanesulfonate | Oakwood Chemicals | MFCD00209623 | 536.100 | C3F9O9S3Y | 98.000 | [Y+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F | 1g | 480150732
Yttrium(III) trifluoromethanesulfonate | Oakwood Chemicals | 52093-30-8 | MFCD00209623 | 536.100 | C3F9O9S3Y | 98.000 | [Y+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F | 1g | 480150732
Hampton Research HR2-947-A4/Grid Screen Sodium Malonate #A4/Grid Screen Salt HT (C4), 185 ml - 2.4 M Sodium malonate pH 4.0
HR2-947-A4/Grid Screen Sodium Malonate #A4/Grid Screen Salt HT (C4), 185 ml - 2.4 M Sodium malonate pH 4.0. Please note items from this supplier are non-returnable.
Medchemexpress LLC FL118-C3-O-C-amide-C-NH2-d5 formate | 587.59 | 5 MG
FL118-C3-O-C-amide-C-NH2-d5 formate is a deuterium-labeled FL118-C3-O-C-amide-C-NH2 formate, an ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled compound
- Used as an ADC linker
- Applicable in the synthesis of antibody-drug conjugates (ADCs)
- Heavy isotopes can serve as tracers for quantitation during drug development
- Deuteration may impact pharmacokinetic and metabolic profiles of drugs