Organometallic Compounds
Medchemexpress LLC M-PEG5-Br | 854601-80-2 | 98.0% | C11H23BrO5 | 10 G
m-PEG5-Br is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one ligand targeting an E3 ubiquitin ligase and the other targeting the protein of interest. These compounds function by exploiting the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
![eMolecules Pharmablock / 5-bromo-2-(2-trimethylsilylethoxymethyl)pyrazole-3-carbonitrile / 25mg / 746320065 / PBXAA1114 / 0.000 / 1637595-30-2 / [null] / 302.247 / C10H16BrN3OSi](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502465064.JPG-250.jpg)
eMolecules Pharmablock / 5-bromo-2-(2-trimethylsilylethoxymethyl)pyrazole-3-carbonitrile / 25mg / 746320065 / PBXAA1114 / 0.000 / 1637595-30-2 / [null] / 302.247 / C10H16BrN3OSi
Pharmablock / 5-bromo-2-(2-trimethylsilylethoxymethyl)pyrazole-3-carbonitrile / 25mg / 746320065 / PBXAA1114 / 0.000 / 1637595-30-2 / [null] / 302.247 / C10H16BrN3OSi
Cayman Chemical Tubastatin A trifluoroacetat
Potent HDAC6 inhibitor (IC50 = 15 nM) with 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM); induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures; displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM
eMolecules 5-(TERT-BUTYLDIMETHYLSILYLOXY)-4,4-DIMETHYL-3-OXOPENTANENITRILE | 1229454-44-7 | MFCD26399496 | 1g
AstaTech | 5-(TERT-BUTYLDIMETHYLSILYLOXY)-4,4-DIMETHYL-3-OXOPENTANENITRILE | 1g | 411869522 | 21246 | 95.000 | 1229454-44-7 | MFCD26399496 | 255.433 | C13H25NO2Si
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Cayman Chemical Tubastatin A trifluoroacetat
Potent HDAC6 inhibitor (IC50 = 15 nM) with 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM); induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures; displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM
Medchemexpress LLC N-(Azido-PEG2)-N-bis(PEG4-Boc) | 2112731-81-2 | C36H70N4O14 | 100 MG
N-(Azido-PEG2)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an azide group.
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
eMolecules Chem-Impex Trimethylsilyl trifluoromethanesulfonate 5kg 213790636 24444 0 000 27607-77-8 MFCD00000406 222 250 C4H9F3O3SSi
Chem-Impex Trimethylsilyl trifluoromethanesulfonate 5kg 213790636 24444 0 000 27607-77-8 MFCD00000406 222 250 C4H9F3O3SSi
Apexbio Technology LLC Epidermal Growth Factor Receptor Peptide (985-996) 96249-43-3 10mg
Epidermal Growth Factor Receptor Peptide (985-996) (CAS 96249-43-3) corresponds to a C-terminal segment of the EGFR protein involved in receptor autophosphorylation EGFR a transmembrane receptor tyrosine kinase undergoes activation upon ligand binding triggering receptor dimerization and subsequent phosphorylation of specific tyrosine residues within its C-terminus including the 985-996 region This phosphorylation facilitates recruitment of SH2 domain-containing signaling proteins thereby initiating pathways such as MAPK Akt and JNK which regulate cell proliferation migration and adhesion This peptide serves as a useful research tool for elucidating EGFR-mediated signaling and studying kinase-substrate interactions in cellular models
eMolecules Potassium (2-trimethylsilyl)ethynyltrifluoroborate | 485339-09-1 | MFCD11052737 | 1g
Combi-Blocks | Potassium (2-trimethylsilyl)ethynyltrifluoroborate | 1g | 517032098 | QC-6682 | 95.000 | 485339-09-1 | MFCD11052737 | 204.120 | C5H9BF3KSi
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Medchemexpress LLC GSK2807 trifluoroacetate | 2245255-66-5 | 99.8% | 566.53 | C21H33F3N8O7 | 100 MG
GSK2807 trifluoroacetate is a SAM-competitive small-molecule inhibitor of the histone methyltransferase SMYD3, reported with Ki = 14 nM and IC50 = 130 nM. It is provided as the trifluoroacetate salt for research use in biochemical and cell-based studies of methylation-dependent signaling.
- High potency against SMYD3 (Ki = 14 nM; IC50 = 130 nM).
- SAM-competitive mechanism of action.
- Supplied as trifluoroacetate (TFA) salt.
- High chemical purity (>99.8%).
- Molecular weight 566.53 g/mol.
- Suitable for biochemical and cell-based assay development.
eMolecules 3-(TERT-BUTYLDIMETHYLSILYLOXY)PROPAN-1-AMINE | 115306-75-7 | MFCD18206137 | 1g
AstaTech | 3-(TERT-BUTYLDIMETHYLSILYLOXY)PROPAN-1-AMINE | 1g | 273176314 | AB10765 | 95.000 | 115306-75-7 | MFCD18206137 | 189.374 | C9H23NOSi
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Apexbio Technology LLC OSI-420 free base 183321-86-0 5mg
OSI-420 free base (CAS 183321-86-0) is an active metabolite of erlotinib (OSI-774) exhibiting inhibitory activity against epidermal growth factor receptor (EGFR) tyrosine kinase Mechanistically OSI-420 inhibits EGFR by binding competitively to the ATP-binding site within the intracellular kinase domain thus preventing receptor autophosphorylation and subsequent signaling Additionally through EGFR inhibition it can trigger apoptosis via mitochondrial disruption including loss of mitochondrial membrane potential and cytochrome c release OSI-420 is utilized in biomedical research for studying EGFR-related signaling pathways and apoptosis mechanisms
eMolecules 2-AMINO-3,3,3-TRIFLUOROPROPAN-1-OL HCL | 1196154-75-2 | MFCD10697731 | 1g
AstaTech | 2-AMINO-3,3,3-TRIFLUOROPROPAN-1-OL HCL | 1g | 323624613 | N11384 | 95.000 | 1196154-75-2 | MFCD10697731 | 165.540 | C3H7ClF3NO
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Medchemexpress LLC Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate | 632-93-9 | MFCD00005950 | 99.8% | 267.32 g·mol-1 | C14H21NO4 | 500 MG
Diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate is a synthetic dihydropyridine derivative supplied as a white to off-white powder for research use. It is used as a reference standard in biochemical and pharmacological studies and is reported to inhibit ferrochelatase, interfering with heme synthesis pathways.
- High purity suitable for analytical and research applications.
- Molecular weight 267.32 g·mol-1 and chemical formula C14H21NO4.
- White to off-white solid supplied as a powder.
- Store powder at -20°C for long-term or 4°C for short-term; store in solvent at -80°C for extended stability.
- Common applications include biochemical assays and studies of heme biosynthesis.
Medchemexpress LLC Silane, [[(1a,3b,5e,7e,22e)-9,10-secoergosta-5,7,10(19),22-tetraene-1,3-diyl]bis(oxy)]bis[(1,1-dimethylethyl)dimethyl- | 111594-58-2 | 99.6% | C₄₀H₇₂O₂Si₂ | 250 MG
Silane, [[(1a,3b,5E,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraene-1,3-diyl]bis(oxy)]bis[(1,1-dimethylethyl)dimethyl- is a drug intermediate used for the synthesis of various active compounds. It is intended for research use only and is not sold to patients.
- Drug intermediate for synthesis of various active compounds.
- Intended for research use only.
- Not sold to patients.