Organometallic Compounds

Medchemexpress LLC Abemaciclib (methanesulfonate) | 1231930-82-7 | 99.8% | 602.70 | 1ML

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Abemaciclib methanesulfonate is a selective and BBB-permeable CDK4/6 inhibitor. It exhibits IC50s of 2 nM for CDK4 and 10 nM for CDK6. This product is suitable for use as a laboratory chemical and in the manufacture of substances.

• Selective and BBB-permeable CDK4/6 inhibitor
• IC50s of 2 nM for CDK4 and 10 nM for CDK6
• Suitable for laboratory chemical applications
• Can be used in the manufacture of substances
• Appears as a solid
• Recommended storage at 4°C, sealed and away from moisture
• Solvent storage at -80°C for 2 years or -20°C for 1 year
• Ships at room temperature if less than 2 weeks

Medchemexpress LLC Abemaciclib (methanesulfonate) | 1231930-82-7 | 99.8% | 602.70 | 200 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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This compound is a selective and BBB-permeable inhibitor of CDK4/6, with half-maximal inhibitory concentrations (IC50s) of 2 nM and 10 nM for CDK4 and CDK6, respectively.

• Selective inhibition of key enzymes involved in cell cycle regulation.
• Permeates the blood-brain barrier.
• Reduces cell viability in various human cell lines, including HCT-116, MCF7, and PANC-1.
• Inhibits Rb phosphorylation, leading to a G1 arrest and suppressed proliferation.
• Activity is specific for cells that are proficient in Rb.
• Effective in reducing cell viability across multiple cancer cell lines.
• Demonstrates antiproliferative activity against human HCT116 and MCF7 cells.
• Shows inhibition in resistant cell lines.
• Causes a cooperative antitumor effect when combined with other agents in xenograft models.
• Leads to significant tumor growth inhibition in xenograft models.

Medchemexpress LLC Abemaciclib methanesulfonate (LY2835219 methanesulfonate) | 1231930-82-7 | 99.8% | 50 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Abemaciclib methanesulfonate (LY2835219 methanesulfonate) | 1231930-82-7 | 99.8% | 50 MG

eMolecules​ Synthonix - Stock 3-tert-Butyldimethylsilyloxypropanal 250mg 495873820 B64752 0 000 89922-82-7 MFCD04039464 188 342 C9H20O2Si

Synthonix - Stock 3-tert-Butyldimethylsilyloxypropanal 250mg 495873820 B64752 0 000 89922-82-7 MFCD04039464 188 342 C9H20O2Si

eMolecules​ Combi-Blocks Inc. 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal 1g 603138890 QH-0157 96.000 89922-82-7 MFCD04039464 188.342 C9H20O2Si

Combi-Blocks Inc. 3-[(tert-Butyldimethylsilyl)oxy]-1-propanal 1g 603138890 QH-0157 96.000 89922-82-7 MFCD04039464 188.342 C9H20O2Si