Solvents
![Revvity Health Sciences Inc D- (+) Biotin, [3H(G)]- 250 µCi](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502105564.jpg-250.jpg)
Apexbio Technology LLC XL335 629664-81-9 10mM (in 1mL DMSO)
XL335 (CAS 629664-81-9) is a selective orally bioavailable agonist of the farnesoid X receptor (FXR) displaying an EC50 of approximately 4 nM In Hep3B liver cancer cells XL335 activation of FXR reduces interleukin-6-induced C-reactive protein (CRP) expression at both mRNA and protein levels In vivo studies indicate that XL335 diminishes lipopolysaccharide (LPS)-stimulated inflammatory responses and fructose-induced hepatic inflammation by suppressing acute-phase proteins (e g SAP SAA3) and adipose differentiation-related protein (ADRP) Thus XL335 serves as a valuable tool for investigating FXR-mediated pathways involved in liver inflammation and metabolic disorders
Apexbio Technology LLC BIBR 1532 321674-73-1 10mM (in 1mL DMSO)
BIBR 1532 (CAS 321674-73-1) is a selective non-nucleosidic inhibitor of telomerase exhibiting an IC50 of approximately 93 nM It targets human telomerase reverse transcriptase (hTERT) reducing enzymatic activity and causing telomere shortening Mechanistically BIBR 1532 suppresses cancer cell proliferation and induces apoptosis by modulating c-Myc and hTERT transcription elevating pro-apoptotic signaling through p73 Bax/Bcl-2 ratio and caspase-3 activation It has demonstrated inhibitory effects on proliferation and survival in several leukemia cell lines including pre-B acute lymphoblastic leukemia and acute promyelocytic leukemia (NB4) highlighting its utility in oncology research
Apexbio Technology LLC NSC23766 trihydrochloride 1177865-17-6 10mM (in 1mL DMSO)
NSC23766 trihydrochloride (CAS 1177865-17-6) is a selective inhibitor of the Rac1 GTPase It functions by binding specifically to guanine nucleotide exchange factors (GEFs) such as Trio and Tiam preventing their interaction with Rac1 and thus inhibiting Rac1 activation NSC23766 demonstrates an IC50 of approximately 50 M It has been used in various cellular models to study Rac1-dependent processes including endothelial barrier integrity and apoptosis regulation By modulating Rac1 activity NSC23766 serves as a tool compound for investigating the role of Rac signaling pathways in cellular apoptosis especially TNF- -induced JNK activation and barrier function dynamics
Apexbio Technology LLC Eptifibatide 188627-80-7 10mM (in 1mL DMSO)
Eptifibatide is a cyclic heptapeptide belonging to the glycoprotein IIb/IIIa inhibitor category functioning as an antagonist of platelet adhesion by reversibly binding to the platelet glycoprotein IIb/IIIa receptor This receptor located on platelet surfaces mediates platelet aggregation through binding fibrinogen and von Willebrand factor processes essential in thrombus formation By blocking the GP IIb/IIIa receptor binding site Eptifibatide inhibits fibrinogen-dependent platelet cross-linking reducing platelet aggregation In biomedical research Eptifibatide serves as a pharmacological tool to investigate platelet function thrombosis mechanisms and related cardiovascular diseases in preclinical and clinical models
Sigma Aldrich Fine Chemicals Biosciences Ethylene glycol d6 98 atom5G
Ethylene glycol-d6 is a deuterated NMR solvent useful in NMR-based research and analyses. Its infrared spectrum has been recorded.
