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ISOGRO(R) media is required for overcoming the growth limitations of minimal media. ISOGRO products are lysates of algae grown with stable isotopes (13C 15N and/or D). ISOGRO(R)-13C powder -growth medium gives uniform labeling for protein expression NMR (nuclear magnetic resonance) studies.A typical algal lysate (ISOGRO medium) contains 30% salts 3% water 2% glucose and 65% amino acids/peptides.
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2-Naphthol-d7 is the deuterium labeled 2-Naphthol[1] 2-Naphthol is a metabolite of naphthalene catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1 CYP 1A2 CYP 2A1 CYP 2E1 and CYP 2F2)[2]
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Melamine-13C3 is the 13C labeled Melamine[1] Melamine is a metabolite of cyromazine Melamine is a intermediate for the synthesis of melamine resin and plastic materials[2]
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Argatroban is a synthetic small-molecule inhibitor acting as a direct binder to thrombin s active site thereby blocking the thrombin-mediated conversion of fibrinogen into fibrin It competitively inhibits thrombin-induced platelet activation and blood clot formation exhibiting an inhibitory constant (Ki) of approximately 19 nM Due to its specificity and direct mechanism Argatroban is frequently employed in experimental research scenarios to investigate thrombin-dependent coagulation pathways platelet aggregation studies and antithrombotic effects in various in vitro assays and animal thrombosis models
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YM155 (Sepantronium Bromide CAS 781661-94-7) is a small-molecule inhibitor targeting survivin the smallest protein member of the inhibitor of apoptosis (IAP) gene family YM155 potently suppresses survivin expression while demonstrating minimal influence on other IAP family members or BCL-2-associated proteins Preclinical research shows YM155 inhibits proliferation and induces apoptosis across various human cancer cell lines including non-small cell lung cancer (NSCLC) melanoma bladder cancer aggressive non-Hodgkin lymphoma triple-negative breast cancer (TNBC) and Wilms tumor models In animal xenograft studies YM155 administration results in tumor regression reduces spontaneous metastasis and notably prolongs survival
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