Solvents
Research Products International Corp TS-2 Tissue and Gel Solubilizer, Scintillation Grade, 500 Milliliters
TS-2 is a strong organic base formulated to solubilize biological materials. Its high water holding capacity will incorporate up to 450 mg of aqueous volume using just 1 ml of TS-2. This factor alone makes TS-2 an economical product to use. TS-2 is compatible with all aromatic hydrocarbon based scintillation cocktails and eliminates problems related to chemiluminescence. This provides accurate sample reproducibility.
The ratio of sample weight or volume to the TS-2 volume will vary. Some typical examples are listed below:
Sample Volume TS-2 Volume Plasma - 0.4ml to 1.0ml
Dilute Nucleic Acids - 0.5ml to 1.0ml
Dilute Amino Acids - 0.5ml to 1.0ml
Protein Homogenates - 0.4ml to 1.0 ml
Most sample digestion can be performed at room temperature, which also reduces the effects of color quenching.
Apexbio Technology LLC CEP-18770 847499-27-8 10mM (in 1mL DMSO)
CEP-18770 (CAS 847499-27-8) is a reversible boronic acid-based inhibitor of proteasome chymotrypsin-like activity It specifically targets the proteasome s P2 threonine protease subunit reducing NF- B signaling and the expression of downstream effectors With a reported IC50 of 3 8 nM CEP-18770 induces apoptosis in multiple myeloma cell lines and inhibits osteoclastogenesis and angiogenesis via suppression of RANKL signaling Research supports its potential use in oncology particularly for multiple myeloma showing selective cytotoxicity sparing normal epithelial and bone marrow-derived cells
Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 10mM (in 1mL DMSO)
Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
Sigma Aldrich Fine Chemicals Biosciences Polyethylene glycol averag20KG
Poly (ethylene glycol) (PEG) is non-ionic hydrophilic and non-toxic polymer. It is widely used in the emerging field of polymerA€based drug delivery. PEG is available in different molecular weights. It facilitates the purification and crystal growth of proteins and nucleic acids. PEG and dextran together result in aqueous polymer two phase system which is required for the purification of biological materials. It also interacts with cell membrane thereby allowing cell fusion.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran d8 99.5 at
Tetrahydrofuran-d8 (THf-d8 TDf) is a deuterated NMR solvent useful in NMR-based research and analyses. 1H NMR line shape analysis of the exchange rates of proton between methanol and acetic acid dissolved in THf-d8 was reported. It participates as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium. Dynamic NMR spectroscopic study of 15N 15NAE-dipentadeuterophenylformamidine (DPfA) has been studied in THf-d8.
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
GFS Chemicals Inc ACETONITRILE, HPLC, GRADIENT GRADE | 4 X 4 L | GFS CHEMICALS, INC. Item #: 10544 | Bulk #: 2482
ACETONITRILE, HPLC, GRADIENT GRADE | Chemical Formula : CH!3CN | CAS # : 75-05-8 | Specifications : Assay 99.9 % - Min, Color (APHA) 10 , LC Gradient Suitability, Residue after evaporation 2 ppm , Titrable acid 0.008 meq/g , Titrable base 0.0006 meq/g , UV Absorbance @ 190 nm 1.00 , UV Absorbance @ 200 nm 0.05 , UV Absorbance @ 210 nm 0.03 , UV Absorbance @ 220 nm 0.02 , UV Absorbance @ 254-400 nm 0.005 , Water 0.01 %
Apexbio Technology LLC Betacarotene 7235-40-7 10mM (in 1mL Ethanol)
Betacarotene (CAS 7235-40-7) is a hydrocarbon-based tetraterpenoid pigment widely present in plants and fruits Structurally composed of eight isoprene units (40 carbon atoms) arranged linearly with terminal beta-ring formations betacarotene exhibits potent antioxidant characteristics Biologically it serves as a precursor to vitamin A (retinol) undergoing oxidative cleavage to retinoids and thus modulates the activity of retinoic acid receptors involved in gene transcription Betacarotene s antioxidant properties enable it to scavenge reactive oxygen species mitigating oxidative damage in cellular models It is frequently studied in vitro and in vivo to investigate mechanisms underlying oxidative stress inflammation and vitamin A metabolism pathways
Sigma Aldrich Fine Chemicals Biosciences 2 Methyltetrahydrofuran Bi
We are committed to bringing you Greener Alternative Products which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with Safer Solvents and Auxiliaries and Use of Renewable Feedstocks. Click here for more information.2-Methyltetrahydrofuran (2-MTHF) a 2-methyl substituted tetrahydrofuran is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide.
Apexbio Technology LLC AM095 1345614-59-6 10mM (in 1mL DMSO)
AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies
Apexbio Technology LLC AGN 194310 229961-45-9 10mM (in 1mL DMSO)
AGN 194310 is a pan-retinoic acid receptor (RAR) antagonist with affinity for RAR RAR and RAR It binds these receptors with Kd values of 3 nM 2 nM and 5 nM respectively By competing with RAR agonists AGN 194310 blocks receptor-mediated cellular responses In cell-based assays AGN 194310 inhibits the proliferation and colony formation of prostate carcinoma cell lines (LNCaP PC3 DU-145) induces G1 cell cycle arrest and promotes apoptosis In addition it suppresses agonist-induced differentiation in HL60 cells AGN 194310 serves as a research tool to investigate RAR-driven signaling pathways and tumor cell growth mechanisms particularly in oncology studies examining retinoid receptor functions
Apexbio Technology LLC Avasimibe 166518-60-1 10mM (in 1mL DMSO)
Avasimibe (CAS 166518-60-1) is an orally bioavailable inhibitor of acyl-coenzyme A cholesterol acyltransferase (ACAT) an enzyme involved in cholesterol esterification It exhibits potent inhibition with an IC50 of approximately 60 nM In cell-based studies avasimibe reduces intracellular cholesterol esters in a dose-dependent manner without elevating free cholesterol levels suggesting an advantageous safety profile Additionally avasimibe reduces synthesis and secretion of Apo B 100 a constituent of very low-density lipoprotein (VLDL) in HepG2 cells and increases bile acid synthesis in rat hepatocytes Beyond dyslipidemic modulation and anti-atherogenic activities it influences amyloid precursor protein (APP) trafficking reducing its maturation and subsequent amyloid-beta (A ) peptide generation providing avenues for Alzheimer s disease research
Sigma Aldrich Fine Chemicals Biosciences 2 Methyltetrahydrofuran Bi
We are committed to bringing you Greener Alternative Products which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with Safer Solvents and Auxiliaries and Use of Renewable feedstocks. Click here for more information.2-Methyltetrahydrofuran (2-MTHf) a 2-methyl substituted tetrahdrofuran is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THf) and diethyl ether. The ring opening reaction of 2-MTHf has been studied using acid chloride and iodide to form secondary chlorides and primary iodides respectively. On long term storage tetrahydrofuran forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals re
Sigma Aldrich Fine Chemicals Biosciences 2 Methyltetrahydrofuran Bi1L
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with Safer Solvents and Auxiliaries and Use of Renewable Feedstocks. Click here for more information.2-Methyltetrahydrofuran (2-MTHF), a 2-methyl substituted tetrahdrofuran, is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide to form secondary chlorides and primary iodides respectively. On long term storage, tetrahydrofuran forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals re
Sigma Aldrich Fine Chemicals Biosciences 2 Methyltetrahydrofuran Bi
We are committed to bringing you Greener Alternative Products which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with Safer Solvents and Auxiliaries and Use of Renewable feedstocks. Click here for more information.2-Methyltetrahydrofuran (2-MTHf) a 2-methyl substituted tetrahdrofuran is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THf) and diethyl ether. The ring opening reaction of 2-MTHf has been studied using acid chloride and iodide to form secondary chlorides and primary iodides respectively. On long term storage tetrahydrofuran forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals re
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