Aminosaccharides
Apexbio Technology LLC D-+-Galactosamine 1772-03-8 100mg
D-plus-Galactosamine is a small-molecule agent used to induce hepatocellular injury for research applications It functions by disrupting the intracellular metabolism of uridine diphosphate (UDP)-sugars consequently impairing glycoprotein and glycolipid biosynthesis and triggering metabolic disturbances in hepatocytes D-plus-Galactosamine exerts its biological activity primarily through the induction of hepatocellular damage inflammatory responses and apoptotic signaling cascades via UDP-sugar metabolic disruption Based on these pharmacological properties D-plus-Galactosamine holds research potential in modeling acute hepatic injury studying hepatitis pathogenesis and liver dysfunction investigating inflammation-mediated hepatocyte death mechanisms and evaluating hepatoprotective strategies
Sigma Aldrich Fine Chemicals Biosciences Dihydrostreptomycin sesquisulfate | 5490-27-7 | MFCD00070252 | 5g
Dihydrostreptomycin sesquisulfate | Mol Wt: 730.71 | 5490-27-7 | MFCD00070252 | 5g
Selleck Chemical LLC Hyaluronic acid-25mg
Hyaluronic acid (HA, Hyaluronan, Hyaluronate) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is widely used in skin care.
Sigma Aldrich Fine Chemicals Biosciences 4-Methylumbelliferyl N-Acetyl-Beta-D-Glucosaminide | 37067-30-4 | MFCD00065481 | 1g
4-Methylumbelliferyl N-Acetyl-Beta-D-Glucosaminide | Mol Wt: 379.36 | 37067-30-4 | MFCD00065481 | 1g
Apexbio Technology LLC Apramycin Sulfate 65710-07-8 100mg
Apramycin Sulfate (65710-07-8) is an aminoglycoside antibiotic targeting bacterial ribosomal RNA It is designed to bind to the ribosomal RNA s conserved deep groove region thereby inhibiting bacterial protein synthesis Apramycin Sulfate exerts its biological activity primarily through specific interaction with bacterial ribosomal RNA leading to inhibition of protein synthesis and disruption of bacterial cell growth In experimental assays Apramycin Sulfate demonstrates inhibitory activity against various bacterial strains with reported IC50 values ranging from 1 to 10 g/mL depending on the strain and experimental conditions Based on these pharmacological properties Apramycin Sulfate holds research potential in antibacterial mechanism studies ribosomal structure-function analyses and resistance mechanism research
Medchemexpress LLC Abt-418 hydrochloride | 147388-83-8 | 99.4% | 202.68 | C9H15ClN2O | 10 MG
ABT-418 hydrochloride is the hydrochloride salt of a selective neuronal nicotinic acetylcholine receptor (nAChR) agonist used for preclinical research. It is supplied as a light brown to brown solid, with characterized purity and solubility suitable for formulation and biological testing.
- Selective neuronal nicotinic acetylcholine receptor (nAChR) agonist.
- High purity (99.4%).
- Molecular weight 202.68.
- Water solubility approximately 11.9 mg/mL; requires ultrasonic.
- PBS dissolution up to 100 mg/mL for in vivo formulation.
- Solid, light brown to brown appearance; store sealed away from moisture at 4°C.
- Available in small research pack sizes (5 mg-100 mg).
AG Scientific Inc G-418.Sulfate, 50G
G-418 Sulfate Salt (Geneticin) is an aminoglycoside antibiotic that is synthesized from Micromonospora rhodorangea and functions by causing a chain of nonsense mutations during translation. Due to translation G-418 inhibited polypeptide synthesis and protein elongation. G-418 binds to the 80S subunit of the ribosome by blocking the elongation phase of protein synthesis, both in prokaryotic and eukaryotic cells. It also shows activity against protozoa, cecal amoebiasis, and helminthes.CAS Number: 108321-42-2Molecular Weight: 692.7 DaChemical Formula: C20H40O10N4 2H2SO4Solubility: Soluble in water: 100mg/ml, colorless solutionStorage Temperature: +4CResearch or further manufacturing use only, not for food or drug use.
Medchemexpress LLC Azidoethyl-SS-PEG2-Boc | 2144777-83-1 | 351.49 | 250 MG
Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
- PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 1 G
D(+)-Galactosamine hydrochloride is an established experimental toxin known to primarily cause liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, often leading to renal failure associated with end-stage liver damage. This compound can be used to induce hepatitis models, mimicking viral hepatitis by causing lipid peroxidation and cell membrane deterioration.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Causes caspase-3 activation and DNA fragmentation.
- Used as an animal model for fulminant hepatic failure.
- Induces acute liver failure in mice when co-administered with Lipopolysaccharide.