Monosaccharides
Medchemexpress LLC Sitagliptin (phosphate) | 654671-78-0 | 99.6% | 505.31 | 200 MG
Sitagliptin phosphate is an orally active and highly selective DPP4 inhibitor that blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), thereby increasing active incretin levels. This compound has demonstrated protective effects on pancreatic islet grafts in type 1 diabetes models and is useful for the study of both type 1 and type 2 diabetes.
- Orally active and highly selective DPP4 inhibitor
- Blocks degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP)
- Increases active incretin levels
- Directly stimulates GLP-1 secretion by intestinal L cells via cAMP/PKA and ERK1/2 pathways
- Shows protective effects on pancreatic islet grafts in type 1 diabetes models
- Suitable for studying type 1 and type 2 diabetes
Apexbio Technology LLC DL-α-Hydroxyglutaric acid disodium salt 40951-21-1 25mg
DL- -Hydroxyglutaric acid disodium salt (CAS 40951-21-1) is a small molecule analogue of -hydroxyglutaric acid a metabolite implicated in neurometabolic disorders In humans aberrant accumulation of D- -hydroxyglutaric acid occurs in D-2-hydroxyglutaric aciduria associated with mutations in isocitrate dehydrogenase (IDH) enzymes particularly IDH1 and IDH2 These mutations alter normal metabolic flux leading to overproduction of D- -hydroxyglutaric acid from 2-oxoglutarate In preclinical studies elevated levels of this metabolite are detectable in IDH1-mutant glioma models and non-invasive quantification is feasible via magnetic resonance spectroscopy DL- -Hydroxyglutaric acid disodium salt is utilized in research investigating metabolic dysregulation biomarker development and disease mechanisms linked to IDH mutations and gliomagenesis
Medchemexpress LLC Disodium 6,6′-oxybis(2-naphthalenesulfonate) | 61551-82-4 | >95.0% | 474.41 g/mol | C20H12Na2O7S2 | 1 MG
Disodium 6,6′-oxybis(2-naphthalenesulfonate) is a disodium salt commonly encountered as an impurity of the food dye Sunset Yellow FCF. It is provided as a research-grade solid for formulation and synthetic applications where surfactant or dispersant properties are required.
- Acts as a surfactant, emulsifier, and dispersant.
- Applicable in polymer, pharmaceutical, and agrochemical syntheses.
- Off-white solid with a defined molecular formula and molecular weight.
- Identified by CAS number for unambiguous chemical reference.
- Available in small, precisely weighed research pack sizes for lab use.
Medchemexpress LLC Pemetrexed disodium hemipenta hydrate | 357166-30-4 | 99.78% | 1 ML
Pemetrexed disodium hemipenta hydrate is a CNS-penetrant antifolate. Its pentaglutamate form inhibits thymidylate synthase (TS) with a Ki value of 1.3 nM, dihydrofolate reductase (DHFR) with a Ki value of 7.2 nM, and glycinamide ribonucleotide formyltransferase (GARFT) with a Ki value of 65 nM. Its antitumor activity may stem from simultaneous and multiple inhibition of several key folate-requiring enzymes via its polyglutamated metabolites. It is a novel classical antifolate.
- CNS-penetrant antifolate
- Inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT)
- Potential antitumor activity through polyglutamated metabolites
- Soluble at 10 mM in water
Medchemexpress LLC Baricitinib phosphate | 1187595-84-1 | C16H20N7O6PS | 500 MG
Baricitinib phosphate is a selective, orally bioavailable inhibitor targeting JAK1 and JAK2 pathways. It demonstrates potent inhibition of JAK signaling and function in various cellular assays, making it suitable for research applications.
- Selective JAK1/JAK2 inhibitor with high potency
- Inhibits IL-6-stimulated STAT3 phosphorylation and MCP-1 production in PBMCs
- Inhibits pSTAT3 stimulated by IL-23 in isolated naive T-cells
- Prevents IL-17 and IL-22 production by Th17 cells
- Demonstrates anti-inflammatory effects in vivo, reducing hind paw swelling and immune cell infiltration
Selleck Chemical LLC Phytic acid dipotassium salt S3326-25mg
Phytic acid dipotassium salt (Phytic acid potassium IP6 (PS)) an endogenous metabolite in rice grain extract and digest inhibits -secretase 1 (BACE1) with IC50 of approximately 0 25 M
Medchemexpress LLC Glucose 6 Phosphate Dehydrogenase Antibody (YA411) | affinity purified | 59 kDa | 100 UL
Glucose 6 Phosphate Dehydrogenase Antibody (YA411) is a rabbit-derived, non-conjugated IgG monoclonal antibody designed to target Glucose 6 Phosphate Dehydrogenase (G6PD). This product is suitable for various research applications, including Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), and Immunoprecipitation (IP), and has demonstrated reactivity in both human and rat samples.
- Rabbit-derived monoclonal antibody
- Non-conjugated IgG format
- Targets Glucose 6 Phosphate Dehydrogenase (G6PD)
- Applications include Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), and Immunoprecipitation (IP)
- Reactive with human and rat samples
- Affinity purified
- Supplied as a liquid formulation
- Store at -20°C for 1 year, avoid freeze/thaw cycles
Medchemexpress LLC Retagliptin phosphate | 1256756-88-3 | 99.7% | 562.36 | 10 MG
Retagliptin phosphate (SP2086 phosphate) is a selective, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. It can be used for type 2 diabetes mellitus (T2DM) research, inhibiting the degradation of GLP-1 and amplifying the incretin effect.
- Selective, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor.
- Available in solid and solution forms.
- For research use only.
- Can be used for type 2 diabetes mellitus (T2DM) research.
- Inhibits the degradation of GLP-1, amplifying the incretin effect.
Sigma Aldrich Fine Chemicals Biosciences 2-Chloroadenosine | 146-77-0 | MFCD00005734 | 50MG
2-Chloroadenosine | Mol Wt: 301.69 | 146-77-0 | MFCD00005734 | 50MG
Chem-Impex International, Inc. Cytosine 1-b-D-arabinofuranoside | MFCD00066487 | 1G
Cytosine 1-b-D-arabinofuranoside, MFCD00066487, 1G
Selleck Chemical LLC D-Ribose
D-ribose is a naturally occurring sugar involved in producing energy in the body and is also the structural basis of DNA and RNA
Alkali Scientific L (+) Arabinose, 1 Kg
L (+) Arabinose, a monosaccharide sugar, is a carbohydrate reagent available in a 1 kg powder form. This chemical is widely used in laboratory settings for various biochemical applications, including metabolic studies and as a carbon source in microbial culture media. Arabinose is a pentose sugar found in plant cell walls and plays an important role in research involving carbohydrate metabolism and enzymatic reactions. In genetic engineering, it is commonly used in studies involving the arabinose operon, which regulates the metabolism of arabinose in microorganisms. This product is high purity and designed for use in research, testing, and pharmaceutical applications.
Medchemexpress LLC Glucose-6-phosphate dehydrogenase | 9001-40-5 | 108.6 kDa | 5KU
Glucose-6-phosphate dehydrogenase (G6PD) from a microorganism is the rate-limiting enzyme of the pentose phosphate pathway. Supplied as an enzymatic preparation (5 KU), it generates NADPH for biochemical and enzymatic assays and is intended for research applications including metabolic studies, antioxidant pathway analysis, and disease models such as diabetes, endothelial dysfunction, cancer, and cardiomyopathy. Refer to the product data sheet and certificate of analysis for purity, storage, and handling instructions.
- Rate-limiting enzyme of the pentose phosphate pathway.
- Provides NADPH for antioxidant and metabolic assays.
- Enzyme activity ≥150 U/mg (solid).
- Specific activity ≥500 U/mg (protein).
- Unit definition: 1 μmol D-glucose 6-phosphate oxidized per min at pH 7.8, 37°C.
- Pack size: 5 KU.
- Source organism: microorganism.
- Purity and storage details available in data sheet and certificate of analysis.