Sugar acids and derivatives
Cayman Chemical QuercetIn 3-O-glucuronIde 10mg
A pharmacologically active flavonol glucuronide; reduced rat immobility time in the forced swim test (0.6 mg/kg); reduced stress-induced hyperthermia in mice (1.2 mg/kg)
Medchemexpress LLC Plantainoside D | 147331-98-4 | 99.9% | 640.59 g/mol | C29H36O16 | 10 MG
Plantainoside D is a phenylethanoid glycoside research reagent reported to inhibit IKK-β and angiotensin-converting enzyme (ACE). It modulates voltage-dependent calcium channels and the PKC signaling cascade, reduces reactive oxygen species and NF-κB activation, and is used in studies of neuroprotection, anti-inflammation, antioxidant activity, and antihypertensive mechanisms.
- Phenylethanoid glycoside with IKK-β and ACE inhibitory activity.
- Modulates VDCCs and suppresses PKC signaling.
- Reduces ROS generation and inhibits NF-κB activation.
- High purity: 99.9%.
- CAS number 147331-98-4.
- Available as 10 MG solid and in DMSO solution formats for assays.
Medchemexpress LLC Integrin alpha 8 bet 50ug
Integrin -8/ -1 coordinates the recruitment of mesenchymal cells during renal organogenesis and recognizes RGD sequences in ligands such as TNC FN1 SPP1 TGFB1 TGFB3 and VTN It plays a role in multiple cellular interactions critical for organogenesis including NPNT as a functional ligand in nephrogenesis Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) is a recombinant protein dimer complex containing human-derived Integrin alpha 8 beta 1 protein expressed by HEK293 with C-10 His C-Flag labeled tag Integrin alpha 8 beta 1 Protein Human (HEK293 Flag His) has molecular weight of 85-140 kDa
Medchemexpress LLC Pentadecanoic acid-d29 | 130348-95-7 | MFCD00053332 | 271.58 | 10 MG
Pentadecanoic acid-d29 is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone. It is for research use only.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Integrin alpha 6 bet 100ug
Integrin alpha 6 beta 1 Protein Human (HEK293 Flag-His) is the recombinant human-derived Integrin alpha 6 beta 1 protein expressed by HEK293 with C-His C-Flag labeled tag has molecular weight of 110 130 kDa respectively
Medchemexpress LLC BET-IN-14 | 2243669-93-2 | C30H37N7O2 | 5 MG
BET-IN-14 is an orally active pan BET inhibitor with an IC50 of 5.35 nM, demonstrating anti-cancer activity. It is intended for research use only.
- Orally active pan BET inhibitor
- Exhibits anti-cancer activity
- High purity (99.07%)
- Solid, light yellow to yellow appearance
- Soluble in DMSO (100 mg/mL)
- Effective against various cancer cell lines (average IC50: 174.7 nM)
- Inhibits tumor growth in MV-4-11 xenograft models
Cayman Chemical D-GlucuronIc AcId 50g
A metabolite of glucose; a component of proteoglycans; levels are increased in fibroblasts isolated from patients with ISSD or Salla disease
Medchemexpress LLC 4-Methylumbelliferyl | 124223-99-0 | MFCD00270047 | 99.0% | 379.36 g/mol | C18H21NO8 | 5MG
4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-galactopyranoside is a fluorogenic glycoside substrate that liberates fluorescent 4-methylumbelliferone upon α-galactosidase-mediated hydrolysis, enabling sensitive fluorometric measurement of enzyme activity in biochemical and cell-based assays.
- Fluorogenic substrate for α-galactosidase assays.
- Releases 4-methylumbelliferone for sensitive fluorescence detection.
- High purity suitable for quantitative measurements.
- Supplied in small-quantity packaging suitable for assay development.
- Solid form; handle and store according to standard glycoside reagent guidelines.
Cayman Chemical D-GlucuronIc AcId 100g
A metabolite of glucose; a component of proteoglycans; levels are increased in fibroblasts isolated from patients with ISSD or Salla disease
Medchemexpress LLC Integrin alpha V bet 20ug | 20ug
Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His C-Avi labeled tag Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) has molecular weight of 90-150 kDa
Medchemexpress LLC Ethanone, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl | 1839150-56-9 | 98.5% | 471.55 | 25 MG
CHMFL-FLT3-122 is a potent, selective, and orally active FLT3 kinase inhibitor with an IC50 of 40 nM. It demonstrates selectivity for FLT3 over BTK (IC50 of 421 nM) and c-KIT (IC50 of 559 nM) kinases. This compound induces apoptosis by arresting the cell cycle in the G0/G1 phase. It is intended for research use only and is not sold to patients.
- Potent, selective, and orally active FLT3 kinase inhibitor
- Induces apoptosis by arresting the cell cycle into the G0/G1 phase
- Significantly inhibits proliferation of FLT3-ITD positive acute myeloid leukemia (AML) cancer cell lines (MV4-11, MOLM13/14)
- Significantly inhibits FLT3 auto-phosphorylation at Tyr589/591 site
- Inhibits phosphorylation of Stat5 ERK, AKT and expression of cMYC
- Can suppress tumor progression in animal models without significantly affecting body weight
Medchemexpress LLC 4-Methylumbelliferyl-β-D-glucuronide hydrate | 881005-91-0 | 99.9% | 1 ML
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrate with an excitation wavelength of 362 nm and an emission wavelength of 445 nm. This compound is used in various enzymatic reactions and has applications in detecting β-glucuronidase activity and quantifying *Escherichia coli*.
- Fluorogenic substrate with λex=362 nm and λem=445 nm
- Detects activity of β-glucuronidase
- Quantifies *Escherichia coli*
- Releases 4-methylumbelliferone in enzymatic reactions
- Suitable for kinase assays to measure GLUase activity
Medchemexpress LLC Integrin alpha V bet 10ug
Integrin V beta 5 proteins specifically the -V (ITGAV) subunit are multifunctional receptors for ligands such as vitronectin and fibronectin and recognize RGD sequences ITGAV ITGB3 binds fractalkine and acts as a coreceptor in CX3CR1-dependent signaling Integrin alpha V beta 8 Protein Human (HEK293 His solution) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 8 protein expressed by HEK293 with C-His labeled tag Integrin alpha V beta 8 Protein Human (HEK293 His solution) has molecular weight of 187 95 kDa
Apexbio Technology LLC Amyloid β-Protein (1-15) 183745-81-5 25mg
Amyloid -Protein (1-15) (CAS 183745-81-5) is a synthetic peptide fragment corresponding to the amino-terminal residues 1 15 of the amyloid -protein Amyloid -protein (A ) is derived from the amyloid precursor protein (APP) and is a major constituent of amyloid plaques observed in the brains of Alzheimer s disease (AD) patients A peptides aggregate extracellularly disrupting synaptic function and neuronal communication The 1 15 fragment is widely used in studies investigating the molecular mechanisms of A aggregation toxicity antibody binding and its potential role in neurodegenerative pathogenesis This fragment serves as a valuable tool for exploring therapeutic strategies targeting A -driven pathology in AD research
Apexbio Technology LLC 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide 140430-53-1 5mg
7-Methoxycoumarin-4-acetyl-P-L-G-L-beta-24-dinitrophenylamino A-R amide (CAS 140430-53-1) is a fluorogenic peptide substrate targeting matrix metalloproteinases (MMPs) It is designed to enable the continuous measurement of MMP enzymatic activity which is achieved by monitoring substrate cleavage between Gly and Leu residues 7-Methoxycoumarin-4-acetyl-P-L-G-L-beta-24-dinitrophenylamino A-R amide exerts its utility through a fluorescence-based mechanism cleavage by MMPs separates the fluorescent reporter group from the quencher resulting in increased fluorescence signal Based on these properties 7-Methoxycoumarin-4-acetyl-P-L-G-L-beta-24-dinitrophenylamino A-R amide is employed in biochemical assays for the quantification of total or specific MMP activity in biological samples and enzyme preparations