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A metabolite of PGE2; does not bind effectively to EP2 and EP4 in CHO cells (Kis = 12 and 57 µM, respectively) or induce adenylate cyclase activity in CHO cells expressing these receptors (EC50s = >18 and >38 µM, respectively); levels are increased in maternal plasma in the third trimester of pregnancy and in women during and immediately after labor and delivery; levels are decreased in tumor tissue isolated from patients with NSCLC
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11β-PGE1 is an epimerized form of PGE1 at the C-11 position. 11β-PGE1 is a less potent isomer of PGE1. It is 13% and 3.6% as potent as PGE1 in contracting the rat uterus and guinea pig ileum, respectively.{4158}
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