Steroids and derivatives
Medchemexpress LLC Estradiol-d2 | 53866-33-4 | >98.0% | 1 MG
Estradiol-d2 is the deuterium-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway. It can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium-labeled estradiol
- Vital for fertility and secondary sexual characteristics
- Upregulates IL-6 expression via ERβ pathway
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 5 MG
Estradiol 3-methyl ether, also known as 3-O-Methyl estradiol, is a synthetic estrogen. This compound has demonstrated the ability to disrupt microtubule networks in V79 cells with an EC50 of 9 μM, and it also inhibits cell proliferation. Furthermore, Estradiol 3-methyl ether has been observed to decrease serum cholesterol levels and contribute to body weight loss, indicating feminizing activity in an HFD murine model. It is intended for research use only.
- Functions as a synthetic version of the hormone estrogen.
- Can disrupt microtubule networks in V79 cells with an EC50 of 9 μM.
- Inhibits the proliferation of cells.
- Decreases serum cholesterol levels.
- Leads to an increase in body weight loss in HFD murine models.
- Exhibits feminizing activity in HFD murine models.
Cayman Chemical Estrone Steroid Hormones
A primary, naturally-occurring estrogen; serum concentrations in premenopausal women fluctuate according to the menstrual cycle; becomes the most predominant estrogen in postmenopausal women; binding affinities to ERα and ERβ are ~60% and ~37% relative to estradiol
Medchemexpress LLC Estrone sulfate (sodium) | 438-67-5 | 99.8% | 372.41 | 25 MG
Estrone sulfate sodium is an inactive endogenous estrogen. It can be converted into Estrone and Estradiol and is a substrate of the OATP1B3 transporter. This compound stimulates the growth of nitrosomethylurea-induced mammary tumors and colony formation of dispersed nitrosomethylurea mammary cells, with conversion to Estrone and Estradiol occurring both in vivo and in vitro.
- Can be converted into Estrone and Estradiol.
- Substrate of the OATP1B3 transporter.
- Stimulates mammary tumor growth in ovariectomized rats.
- Applicable to breast cancer-related research.
Medchemexpress LLC Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 1 MG
Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 1 MG
Medchemexpress LLC 17β-estradiol sulfate sodium | 4999-79-5 | MFCD00056553 | 99.0% | 374.43 g·mol⁻¹ | C18H23NaO5S | 5 MG
17β-estradiol sulfate sodium is the sodium salt of the sulfate metabolite of 17β-estradiol supplied as a solid research reagent. It is used for studies of estrogen metabolism, receptor binding, and neuroactive steroid activity. For research use only; not for human or veterinary use.
- Sodium salt of 17β-estradiol sulfate.
- High purity (99.0%).
- Molecular weight 374.43 g·mol⁻¹.
- Chemical formula C18H23NaO5S.
- Provided as a white to light yellow solid.
- SDS and COA available for quality and safety documentation.
Medchemexpress LLC Estradiol-d2-1 | 3188-46-3 | 5 MG
Estradiol-d2-1 is a deuterium-labeled form of Estradiol, a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression via the estrogen receptor β (ERβ) pathway and is intended for research use only. Deuteration can impact pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis.
- Suitable for NMR, GC-MS, or LC-MS techniques.
- Deuterium-labeled form of estradiol.
- Upregulates IL-6 expression through the ERβ pathway.
eMolecules 79037-37-9 | Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | MFCD01074033 | 275.406 | C18H24O2
Medchem Express | Estradiol-d3 | 1mg | 713707131 | HY-B0141S | 79037-37-9 | MFCD01074033 | 275.406 | C18H24O2
Medchemexpress LLC Alpha-Estradiol | 57-91-0 | MFCD00064144 | 99.5% | 1 G
Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor. It is utilized as a topical medication for the treatment of androgenic alopecia and is classified as a human endogenous metabolite.
- Weak estrogen and 5 alpha-reductase inhibitor
- Inhibits testosterone metabolism catalyzed by 5 alpha-reductase
- Attenuates LPS-induced inflammatory markers in various cell types
- Decreases NFκB-p65 and increases ER alpha protein expression
- Reduces central avascular/total retina area in mouse models
- Decreases malondialdehyde (MDA) levels in hyperoxia-exposed pups
- Reduces NADPH-oxidase-positive cells, concentration, and activity in pup retinas
Apexbio Technology LLC Estradiol Cypionate 313-06-4 1g
Estradiol cypionate (313-06-4) is a small-molecule agonist targeting estrogen receptors (ER) It is designed to activate ER thereby modulating downstream ER-mediated gene transcription and signaling pathways and regulating processes such as vascular homeostasis Estradiol cypionate exerts its biological activity primarily through ER agonism influencing gene expression and inhibiting endothelin-1 (ET-1) synthesis via ER-dependent mechanisms Based on these pharmacological properties estradiol cypionate holds research potential in elucidating estrogen receptor mechanisms and studying estrogen-associated vascular and endocrine systems and disorders
Cayman Chemical 2-bromo 17-EstradIol 10mg
A synthetic steroid and inhibitor of estrogen 2-hydroxylase; inhibits estrogen 2-hydroxylase in rat liver microsomes at 50 and 100 µM; prevents estrogen-induced inhibition of apomorphine-induced climbing behavior in mice at 5 mg/kg
Medchemexpress LLC (R)-Mandelonitrile lyase | 9024-43-5 | 100 U
(R)-Mandelonitrile lyase is an enzyme that can be isolated from *Prunus* species. This product is intended for research purposes only and is not for sale to patients.
- Enzyme that catalyzes the conversion of 1 micromole of substrate per minute
- Related to metabolic or endocrine diseases
- Used in metabolic enzyme/protease applications