Steroids and derivatives
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | 100.0% | 50 MG
Estradiol (Standard) is the analytical standard of Estradiol, intended for research and analytical applications. As a steroid hormone and major female sex hormone, it can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. It is suitable for the research of cancers, neurodegenerative diseases, and neural tissue engineering.
- Reference standard supplied assay
- Commonly used in qualitative, quantitative and methodological research experiments
- Applications include HPLC, GC and MS
Medchemexpress LLC Estradiol-d5 | 221093-45-4 | 99.1% | 1 MG
Estradiol-d5 is a deuterium-labeled form of Estradiol. Estradiol is a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules for quantitation during the drug development process.
Medchemexpress LLC Estradiol 3-methyl ether | 1035-77-4 | 99.9% | 286.41 | 25 MG
Estradiol 3-methyl ether is a synthetic estrogen. It can disrupt microtubule networks in V79 cells with an EC50 of 9 μM and inhibits cell proliferation. Estradiol 3-methyl ether has also been shown to decrease serum cholesterol levels and increase body weight loss, indicating feminizing activity in an HFD murine model.
- Synthetic estrogen
- Disrupts microtubule networks in V79 cells (EC50 of 9 μM)
- Inhibits cell proliferation
- Decreases serum cholesterol levels
- Increases body weight loss in HFD murine models
Cayman Chemical EstradIol CypIonate 5g
A synthetic estrogen; reduces estrogen-depletion induced spikes in basal tail temperature in ovariectomized wild-type, ERα-/-, and ERβ-/- mice at 0.1 mg/kg per day; increases the rate of pregnancy in cows induced to ovulate small dominant follicles; reduces edema and articular joint neutrophil infiltration in an ovariectomized mouse model of zymosan-induced arthritis
Medchemexpress LLC Estradiol 3-sulfamate | 172377-52-5 | 351.46 | 50 MG
Estradiol 3-sulfamate is a potent, long-acting, and orally active steroid sulfatase inhibitor. It inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM. The compound is readily transformed and absorbed in the gut into its oxidative metabolite, EMATE, demonstrating potent and long-acting STS inhibition.
- Potent, long-acting, and orally active steroid sulfatase inhibitor.
- Inhibits estrone sulfatase with an IC50 of 251 nM and a Ki of 133 nM.
- Increased estrone sulfatase inhibitory activity with specific halogen moieties.
- Readily absorbed and transformed in the gut into its oxidative metabolite, EMATE.
- Both compounds demonstrate potent and long-acting STS inhibition.
Alkali Scientific Digitonin, Water Soluble, 500 Milligrams
Digitonin is a water-soluble compound used primarily in membrane permeabilization for research applications. Available in a 500mg format, Digitonin is widely used in cell biology to permeabilize cell membranes, allowing researchers to study intracellular components or deliver compounds directly into cells. It is particularly useful in protein extraction, cellular signaling studies, and in assays that require the breakdown of membrane integrity without damaging the cells entirely. This high-purity product facilitates effective permeabilization while maintaining cellular viability, making it essential for research on cellular processes, membrane proteins, and intracellular interactions.
Cambridge Isotope Laboratories Estradiol (16 16 17-D3 98%) CP 95% 1 mg
Estradiol (16 16 17-D3 98%) CP 95% 1 mg
Apexbio Technology LLC Ethinyl Estradiol 57-63-6 500mg
Ethinyl Estradiol (57-63-6) is a small-molecule estrogen receptor agonist targeting intracellular estrogen receptors It is designed to activate these receptors thereby regulating transcription of estrogen-responsive genes and influencing reproductive biology and cell proliferation pathways Ethinyl Estradiol exerts its biological activity primarily through direct binding to estrogen receptors leading to the modulation of endocrine-regulated mechanisms Based on these pharmacological properties Ethinyl Estradiol holds research potential in studies of receptor-mediated responses endocrine regulation mechanisms synthetic hormone interactions drug interactions contraceptive mechanisms and hormone-dependent physiological processes
Apexbio Technology LLC Estradiol Cypionate 313-06-4 10mM (in 1mL DMSO)
Estradiol cypionate (313-06-4) is a small-molecule agonist targeting estrogen receptors (ER) It is designed to activate ER thereby modulating downstream ER-mediated gene transcription and signaling pathways and regulating processes such as vascular homeostasis Estradiol cypionate exerts its biological activity primarily through ER agonism influencing gene expression and inhibiting endothelin-1 (ET-1) synthesis via ER-dependent mechanisms Based on these pharmacological properties estradiol cypionate holds research potential in elucidating estrogen receptor mechanisms and studying estrogen-associated vascular and endocrine systems and disorders
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | MFCD00003693 | 100.0% | 25 MG
Estradiol (Standard) is an analytical standard of Estradiol, a major female sex hormone and steroid hormone. Intended for research and analytical applications, it can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. This compound is useful for research in cancers, neurodegenerative diseases, and neural tissue engineering.
- Analytical standard grade
- Reference standard for assays
- Utilized in qualitative, quantitative, and methodological research experiments
- Applicable in techniques such as HPLC, GC, and MS
- Supports research in cancers, neurodegenerative diseases, and neural tissue engineering
- Up-regulates neural markers of human endometrial stem cells
- Promotes neural differentiation
Innovative Reseach Of America INNOVATIVE RESEARCH OF AMERICA
NC3903870 0.36 MG 17B ESTRADIOL PELLETS
Medchemexpress LLC Estradiol enanthate | 4956-37-0 | 98.1% | 1 ML
Estradiol enanthate (E2EN) is a shorter-acting estrogen. It is an injectable contraceptive when combined with Dihydroxyprogesterone acetophenide. Estradiol enanthate promotes withdrawal bleeding, similar to menstruation. It is for research use only and not sold to patients.
- Molecular weight: 384.55
- Formula: C25H36O3
- Appearance: Solid
- Color: White to off-white
- SMILES: C[C@@]12[C@@H](OC(CCCCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC2
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, sealed storage, away from moisture and light; In solvent: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture and light)
- Solubility (In Vitro): DMSO: 125 mg/mL (325.06 mM; requires ultrasonic; hygroscopic DMSO impacts solubility, use newly opened DMSO); Ethanol: ≥ 100 mg/mL (260.04 mM)