Purine nucleotides
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 5mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC Uridine diphosphate glucuronic acid | 2616-64-0 | 98.0% | 580.29 g/mol | C15H22N2O18P2 | 1MG
Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a nucleotide sugar cofactor used as the glucuronic acid donor in enzymatic glucuronidation and polysaccharide biosynthesis studies. Supplied as a high-purity research reagent, the product is provided in milligram pack sizes and includes supporting documentation for quality and safe handling.
- High purity (98.0%) suitable for biochemical assays.
- Provided with certificate of analysis and safety data sheet for verification.
- Available in multiple milligram pack sizes to support small-scale experiments.
- Used as a glucuronic acid donor in enzymatic and metabolic studies.
- Stable when stored and handled according to provided instructions.
Sigma Aldrich Fine Chemicals Biosciences Coenzyme A Trilithium Salt | ≥85% Purity | Mol Wt: 767.5 | ®93-18-4-3 | 10 mg
Coenzyme A trilithium salt | Purity: ≥85% | Mol Wt: 767.5 | CAS No: 93-18-4-3 | Biochemical cofactor involved in metabolic pathways and energy production via acyl transfer and thioesterification | 10mg
Medchemexpress LLC ATP Citrate Lyase Antibody (YA829) | Affinity purified | 121 kDa | 100 UL
ATP Citrate Lyase Antibody (YA829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting ATP Citrate Lyase. It is supplied in 1X PBS (pH 7.3), 50% glycerol, and 0.02% sodium azide. This antibody is affinity purified and has an observed molecular weight of 121 kDa. It is stored at -20°C for 1 year, with shipping on blue ice.
- Mouse-derived and non-conjugated IgG2a monoclonal antibody
- Targets ATP Citrate Lyase
- Supplied in 1X PBS (pH 7.3), 50% glycerol, and 0.02% sodium azide
- Affinity purified
- Observed molecular weight: 121 kDa
- Stored at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
- Shipping with blue ice
Medchemexpress LLC Adenosine 5'-diphosphate (disodium) | 16178-48-6 | 99.9% | 1 MG
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate, resulting from ATP dephosphorylation by ATPases. This compound functions as a crucial platelet aggregation agent, playing a significant role in hemostasis and the processes involved in the development and extension of arterial thrombosis.
- Platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis.
- Induces human platelets aggregation and [Ca2+]i increasing in platelets, B10 cells, and P2Y1-transfected cells (at 10 μmol/L).
- Increases cAMP levels in human platelets and in B10 cells (at 5 μmol/L).
Medchemexpress LLC ATP-polyamine-biotin | 1800401-93-7 | 95.0% | 2 MG
ATP-polyamine-biotin is the first cell-permeable ATP analogue and an efficient kinase cosubstrate. It promotes biotin labeling of kinase substrates in live cells. In in vitro studies, when incubated with PKA kinase and full-length myelin basic protein (MBP) substrate, biotinylation was observed only in the presence of the kinase. The biotinylation of MBP was absent without this compound, in the presence of the kinase inhibitor staurosporine, or when incubated with acid, which causes cleavage of the phosphoramidate bond. A biotinylated kemptide product was observed exclusively with this cosubstrate.
- First cell-permeable ATP analogue
- Efficient kinase cosubstrate
- Promotes biotin labeling of kinase substrates in live cells
Medchemexpress LLC ATP dipotassium | 42373-41-1 | 98.7% | 100 MG
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital molecule for energy storage and metabolism in living organisms. It supplies the metabolic energy required to power metabolic pumps and acts as a coenzyme within cells. This compound also plays a crucial role as an endogenous signaling molecule in immunity and inflammation, making it valuable for a wide range of research applications.
- Supports energy storage and metabolism.
- Drives metabolic pumps and acts as a coenzyme.
- Functions as an endogenous signaling molecule in immunity and inflammation.
- Synergistic effect on NLRP3 inflammasome activation with LPS.
- Induces secretion of IL-1β, KC, and MIP-2 from BMDMs.
- Promotes neutrophil chemotaxis.
- Offers protection against bacterial infection in vivo.
- Induces IL-1β, KC, MIP-2 secretion and neutrophil recruitment in vivo.
Medchemexpress LLC Adenosine 5'-triphosphate | 56-65-5 | 99.9% | 1 G
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. It provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is also an important endogenous signaling molecule in immunity and inflammation. It can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. Additionally, ATP has anti-bacterial infection effects and can protect mice against bacterial infection.
- Central component of energy storage and metabolism.
- Provides metabolic energy and acts as a coenzyme.
- Important endogenous signaling molecule in immunity and inflammation.
- Can activate NLRP3 inflammasome and induce IL-1β and chemokines secretion.
- Anti-bacterial infection effects, protecting against bacterial infection in mice.
Medchemexpress LLC Cytarabine triphosph 50mg | 1179343-17-9 | 549.10 | C9H13N3Na3O14P3 | 50 MG
Cytarabine triphosphate trisodium is the active intracellular triphosphate metabolite of cytarabine that competitively inhibits DNA synthesis. Supplied as an aqueous solution, it is intended for biochemical and cellular research requiring the active nucleotide form.
- Active triphosphate metabolite of cytarabine.
- Competitive inhibitor of DNA synthesis.
- Supplied as an aqueous liquid for direct use or dilution.
- Packaged as 50 mg (100 mM, 1 mL) solution.
- Purity about 96.8% and recommended storage at -20°C.
Medchemexpress LLC 7-Methyl-guanosine-5'-triphosphate sodium | 25 MG
7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. Its phosphorothioate analog acts as a potent cap-dependent translation inhibitor.
- Is a guanosine 5'-phosphate.
- Functions as a potent cap-dependent translation inhibitor.
Medchemexpress LLC Adenosine monophosphate | 61-19-8 | MFCD00655082 | 99.7% | C10H14N5O7P | 25 MG
Adenosine monophosphate is provided as an analytical standard, suitable for a variety of research and analytical applications. It functions as an adenosine A1 receptor agonist and exhibits significant antiviral activity against HSV-1 and HSV-2. As a key cellular metabolite, it plays a role in regulating energy homeostasis and signal transduction.
- Intended for research and analytical applications
- Functions as an adenosine A1 receptor agonist
- Possesses significant antiviral activity against HSV-1 and HSV-2
- Key cellular metabolite regulating energy homeostasis and signal transduction
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS