Purine nucleotides
Apexbio Technology LLC GTP-Binding Protein Fragment, G alpha 10mg
GTP-Binding Protein Fragment G alpha is a peptide fragment derived from the amino-terminal region of the alpha subunit of GTP-binding proteins It is designed to aid in elucidating the mechanisms of membrane association and -subunit interactions in cell signaling pathways GTP-Binding Protein Fragment G alpha exerts its biological activity by retaining membrane-binding properties independent of the nucleotide-binding state anchoring the protein to the cytoplasmic membrane surface This peptide fragment serves as an experimental tool to study membrane-association mechanisms and signal transduction pathways in biochemical and biomedical research Based on these properties GTP-Binding Protein Fragment G alpha holds research potential in investigating the molecular basis of G protein-mediated signal transduction and protein-membrane interactions
Medchemexpress LLC Adenosine-15N5 | 168566-57-2 | 99.9% | 272.21 | C10H13(15N)5O4 | 10 MG
Adenosine-15N5 is an isotopically labeled adenosine in which five nitrogen atoms are 15N. It is supplied as a 10 mg solid intended for use as an internal standard, tracer, or reference in mass spectrometry, metabolic studies, and biochemical assays. The material is provided with supporting documentation and handling guidance.
- Isotopically labeled with five 15N atoms.
- High purity (99.9%).
- Molecular weight 272.21 g/mol.
- Supplied as a 10 mg solid vial.
- Soluble in DMSO (33.33 mg/mL); ultrasonic and warming recommended.
- Includes COA, SDS, and handling instructions.
- Suitable as an internal standard or tracer for analytical applications.
Cambridge Isotope Laboratories Adenosine phosphoramidite (U-13C10 98% U-15N5 98%) CP 95% 50 mg
Adenosine phosphoramidite (U-13C10 98% U-15N5 98%) CP 95% 50 mg
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 10mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 50mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC 3H-imidazo[4,5-b]pyridine, 2-ethyl-5,7-dimethyl- | 133240-06-9 | 99.4% | 175.24 g/mol | C10H13N3 | 50 MG
Adenosine receptor antagonist 4 (compound 2) is a small-molecule adenosine A1 receptor antagonist reported with a Ki of 101 nM for the human A1 receptor. It is provided for research use and is characterized by a defined molecular formula and high purity suitable for in vitro pharmacology and receptor-binding studies.
- Cas number 133240-06-9.
- Molecular formula C10H13N3 and molecular weight 175.24 g/mol.
- Purity (HPLC) 99.35%.
- Available in solution (10 mM in DMSO) and solid sizes including 25 mg, 50 mg, and 100 mg.
- Batch-specific COA, data sheet, and SDS are available for handling and quality information.
Cambridge Isotope Laboratories ADENOSINE 13C10 98 1SN10MG
Adenosine (13C10, 98%; 1sN5, 96-98%), 10mg
Cambridge Isotope Laboratories Adenosine phosphoramidite (U-13C10 98%) CP 95% 50 mg
Adenosine phosphoramidite (U-13C10 98%) CP 95% 50 mg