Purine nucleotides
Medchemexpress LLC Adenosine | 58-61-7 | 99.5% | 10 G
Adenosine (Adenine riboside) is a ubiquitous and BBB-permeable endogenous autacoid. It acts through four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine impacts various cellular physiological processes, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Ubiquitous endogenous autacoid.
- BBB-permeable.
- Acts via A1, A2A, A2B, and A3 G protein-coupled receptors.
- Affects neuronal activity.
- Influences vascular function.
- Impacts platelet aggregation.
- Regulates blood cell function.
- Relevant to apoptosis research.
- Relevant to autophagy research.
- Considered an endogenous metabolite.
- Used in metabolic disease research.
- Used in cancer research.
- Classified as a nucleoside antimetabolite/analog.
Medchemexpress LLC Adenosine-N,1,3,7,9-15N5 | 168566-57-2 | 99.9% | 1 MG
Adenosine-15N5 is a 15N labeled form of Adenosine, an endogenous autacoid that interacts with four G protein-coupled receptors (A1, A2A, A2B, and A3). This compound plays a role in various aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. It is suitable for use as a tracer in drug development and for quantitative analysis.
- Used as a tracer during drug development.
- Serves as an internal standard for quantitative analysis.
- Compatible with NMR, GC-MS, or LC-MS techniques.
- Influences cellular processes like neuronal activity and vascular function.
- Impacts platelet aggregation and blood cell regulation.
Medchemexpress LLC Clodronic acid disodium salt | 22560-50-5 | 100.50% | 250 MG
Clodronic acid disodium salt is a first-generation bisphosphonate that acts as an orally active osteoclastic bone resorption inhibitor. It can be utilized in cases of high bone turnover, Paget's disease, and osteolytic bone metastases. It induces rapid apoptosis in osteoclasts by preventing ADP translocation into mitochondria after internalization via resorption, which inhibits ATP production and leads to the release of cytochrome C into the cytoplasm.
- First-generation bisphosphonate
- Orally active osteoclastic bone resorption inhibitor
- Induces apoptosis in osteoclasts
Medchemexpress LLC Adenosine-N,1,3,7,9-15N5 | 168566-57-2 | 99.9% | 5 MG
Adenosine-15N5 is a 15N labeled version of Adenosine, a ubiquitous endogenous autacoid that acts through G protein-coupled receptors A1, A2A, A2B, and A3. It influences various aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. This compound is ideal for use in various research applications.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Influences neuronal activity, vascular function, platelet aggregation, and blood cell regulation
- High purity of 99.9%
- Isotope-labeled compound for drug development studies
Medchemexpress LLC Adenosine | 58-61-7 | 100.0% | 25 G
Adenosine is a ubiquitous and BBB-permeable endogenous autacoid. It acts through four G protein-coupled receptors: A1, A2A, A2B, and A3. This compound impacts nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation. It is for research use only and not sold to patients.
- Acts through four G protein-coupled receptors: A1, A2A, A2B, and A3
- Impacts neuronal activity, vascular function, platelet aggregation, and blood cell regulation
- Ubiquitous and BBB-permeable endogenous autacoid
- Displays cytoprotective function
- Purity: 99.96%
- Molecular weight: 267.25
- Appearance: Solid, white to off-white
Medchemexpress LLC Adenosine 5′-diphosphoribose | 20762-30-5 | 98.2% | 559.32 | C15H23N5O14P2 | 25 MG
Adenosine 5′-diphosphoribose is an endogenous nucleotide derivative used in biochemical and cell biology research to study ADP-ribosylation, DNA damage responses, and TRPM2 channel activation. Supplied as a light yellow powder with defined solubility and storage recommendations, it is suitable for in vitro assays and biochemical experiments.
- Biologically active endogenous nucleotide derivative.
- High purity suitable for biochemical assays (98.2%).
- Light yellow powder form for convenient handling and storage.
- Water soluble (175 mg/mL; ultrasonic may be required for dissolution).
- Stable as a powder at -20°C for long-term storage; in solvent stability is limited.
- Supplied in small research-scale quantities for laboratory use.
Selleck Chemical LLC ATP disodium S1985-1g
ATP disodium is a disodium salt form of adenosine-triphosphate which is a multifunctional nucleoside triphosphate
Cambridge Isotope Laboratories Guanosine phosphoramidite (U-13C10 98% U-15N5 98%) CP 95% 10 mg
Guanosine phosphoramidite (U-13C10 98% U-15N5 98%) CP 95% 10 mg
Sigma Aldrich Fine Chemicals Biosciences Guanosine 5 betagama imi100MG
Guanosine 5prime-[beta gamma-imido]triphosphate (GMP-PNP Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding including GTP-activation GTP-inhibition GTP transport GTP hydrolysis and GTP structure stabilization. Since a cycle of GTP binding hydrolysis and release is required for the initiation of protein translocation across the endoplasmic reticulum guanosine 5prime-[beta gamma-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling protein synthesis and other metabolic processes.
Medchemexpress LLC Inosine 5′-diphosphate sodium | 81012-88-6 | 98.17% | 512.15 | 250 MG
Inosine 5′-diphosphate sodium is a purine ribonucleoside 5′-diphosphate with inosine as the nucleobase. It participates in intracellular energy metabolism and signal transduction processes.
- Purine ribonucleoside 5′-diphosphate with inosine as the nucleobase
- Participates in intracellular energy metabolism
- Participates in signal transduction processes
- Functions as an endogenous metabolite
- Classified as a nucleotide analog
- Used in research for respiratory disease
- Used in research for metabolic or endocrine disease
- Used in research for pulmonary disease
- Used in research for lung fibrosis
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.9% | 681.49 | 5 MG
Sonidegib diphosphate, also known as Erismodegib diphosphate, is a potent and selective Smoothened (Smo) antagonist. It works by directly interacting with Smo to reduce the expression of downstream Hedgehog (Hh) signaling targets. This compound has shown dose-related antitumor activity in medulloblastoma mouse models, effectively inhibiting tumor growth and causing regression at higher doses. It is for research use only.
- Potent and selective Smo antagonist
- Interacts directly with Smo to reduce expression of downstream Hh signaling targets
- Inhibits the Hh pathway in CD34+ chronic phase chronic myeloid leukemia (CML) cells
- Reduces the number and self-renewal capacity of CML leukemia stem cells (LSC)
- Demonstrates dose-related antitumor activity in medulloblastoma allograft mouse models
- Significantly inhibits tumor growth and affords regression at higher doses
Medchemexpress LLC Inosine-5'-diphosphate disodium | 54735-61-4 | 99.1% | 428.19 | 1 G
Inosine-5'-diphosphate disodium | 54735-61-4 | 99.1% | 428.19 | 1 G
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5-diphosphate di1G
REAGENT Adenosine 5-diphosphate di1G
Abcam Iodotubercidin, adenosine kinase inhibitor, 5MG
MW 392.15 Da, Purity >95%. Potent, specific adenosine kinase inhibitor (IC₅₀ = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM).
The product is subject to the following: Abcam Restricted Use Statement