Drug Standards
Medchemexpress LLC Actin Related Protein 2 Antibody (YA2725) | 100 UL
This Actin Related Protein 2 Antibody (YA2725) is a rabbit-host antibody designed for various research applications. It reacts with human, mouse, and rat samples, making it suitable for a broad range of studies.
- Host: Rabbit
- Reactivity: Human, mouse, rat
- Applications: WB (1:500-1:1000), ICC/IF (1:50-1:200)
- Molecular weight: Predicted and observed at 45 kDa
- Concentration: 0.3 mg/mL
- Formulation: Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Storage & Stability: Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles
- Shipping: With blue ice
Medchemexpress LLC Iopamidol | 60166-93-0 | 25 MG
Iopamidol is a nonionic, X-Ray iodinated contrast agent used for a wide range of diagnostic applications. It contains amide and hydroxyl functionalities that can be exploited for the generation of chemical exchange saturation transfer (CEST) contrast. This product serves as an analytical and reference standard, commonly used in qualitative, quantitative, and methodological research experiments.
- Analytical and reference standard
- Used for X-Ray iodinated contrast
- Supports chemical exchange saturation transfer (CEST) contrast generation
- Suitable for qualitative, quantitative, and methodological research experiments
- Applicable in techniques such as HPLC, GC, and MS
- Can be used for pH mapping of kidneys
- Molecular formula: C17H22I3N3O8
- Molecular weight: 777.09
- Appears as a solid
Medchemexpress LLC Betamethasone valerate | 2152-44-5 | 99.8% | 25 MG
Betamethasone valerate, also known as Betamethasone 17-valerate, is the 17-valerate ester of Betamethasone. It functions as a topical corticosteroid with anti-inflammatory activity and is used in the treatment of recurrent aphthous stomatitis. It inhibits the binding of radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin with IC50s of 5 and 6 nM, respectively.
- Topical corticosteroid with anti-inflammatory properties
- Used for recurrent aphthous stomatitis treatment
- Inhibits radiolabeled glucocorticoid binding
- For research use only
Medchemexpress LLC Iodixanol | 92339-11-2 | 99.97% | 5 MG
Iodixanol is an iodine-containing non-ionic radiocontrast agent. It exhibits less kidney toxicity and is intended for research use only.
- Iodine-containing non-ionic radiocontrast agent
- Exhibits less kidney toxicity
- For research use only
Medchemexpress LLC Norfloxacin (MK-0366) | 70458-96-7 | MFCD00079532 | 98.3% | 5 G
Norfloxacin (MK-0366) is a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria. Its mechanism of action involves inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV. These enzymes are crucial for the separation of bacterial DNA, and their inhibition by Norfloxacin consequently prevents bacterial cell division. This synthetic chemotherapeutic antibacterial agent is occasionally utilized to treat both common and complicated urinary tract infections. The product is intended for research use only.
- Broad-spectrum antibiotic
- Effective against Gram-positive and Gram-negative bacteria
- Inhibits DNA gyrase and topoisomerase IV
- Prevents bacterial cell division
- Suitable for research applications
Medchemexpress LLC Oxibendazole | 20559-55-1 | 99.6% | 25 MG
Oxibendazole is an effective benzimidazole anthelmintic that combats nematode infections. It has demonstrated the ability to induce apoptosis and exhibits both anti-cancer and anti-inflammation activities.
- Induces apoptosis
- Active against nematode infections
- Exhibits anti-cancer activities
- Possesses anti-inflammation properties
- Downregulates phosphorylation of ERK1/2, P90RSK, and S6
- Upregulates expression of phosphorylated JNK, AKT, and P70S6K
Medchemexpress LLC Glipizide (Standard) | 29094-61-9 | 99.7% | 25 MG
Glipizide (Standard) is an analytical standard of Glipizide, intended for research and analytical applications. It is a potent, orally active sulfonylurea class anti-diabetic agent used for type 2 diabetes mellitus research.
- Potent, orally active sulfonylurea class anti-diabetic agent
- Used for type 2 diabetes mellitus research
- Acts by partially blocking ATP-sensitive potassium (KATP) channels
- Suitable for qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- IC50: 6.4 nM ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells
Medchemexpress LLC Enalaprilat dihydrate | 84680-54-6 | 98.0% | 25 MG
Enalaprilat dihydrate (MK-422) is the active metabolite of the oral proagent Enalapril. It is a potent, competitive, and long-acting angiotensin-converting enzyme (ACE) inhibitor, making it suitable for hypertension research.
- Potent, competitive, and long-acting ACE inhibitor
- IC50 of 1.94 nM for ACE
- Attenuates IGF-I induced neonatal rat cardiac fibroblast growth in vitro
- Shows significant intraocular pressure (IOP)-lowering effect in rabbits in vivo
Medchemexpress LLC Diphenhydramine hydrochloride | 147-24-0 | 99.93%
Diphenhydramine hydrochloride is a first-generation histamine H1-receptor antagonist exhibiting anti-cholinergic effects. This compound is capable of crossing the ovine blood-brain barrier.
- Inhibits cisplatin-induced cell death in kidney proximal tubular cells.
- Inhibits cell viability in CCRF-CEM and Jurkat cells.
- Induces apoptosis in CCRF-CEM and Jurkat cells.
- Increases expression of Bad and Bax, and decreases BCL-2 level in PANC-1 cells.
- Decreases expression of various phosphorylated proteins (p-AKT, p-mTOR, p-FoxO1, p-MDM2, p-NF-ĸB p65, and p-GSK-3) in PANC-1 cells.
- Inhibits cisplatin-induced kidney toxicity in mice.
- Reduces mortality in rats with acute, severe dichlorvos exposure.
Medchemexpress LLC Ketorolac (tromethamine salt) | 74103-07-4 | 99.5% | 1 ML
Ketorolac tromethamine salt is a non-steroidal anti-inflammatory agent (NSAIA) that acts as a nonselective COX inhibitor. It is provided as a 10 mM solution in 1 mL of DMSO, suitable for laboratory research. It is stable under recommended storage conditions, with specific handling guidelines to ensure its integrity.
- Nonselective COX inhibitor
- IC50s of 20 nM for COX-1 and 120 nM for COX-2
- Purity of 99.53%
- Supplied as a 10 mM solution in DMSO
- Stable under recommended storage conditions
- Causes skin and eye irritation
- May cause respiratory irritation
Medchemexpress LLC (R)-Ketorolac | 66635-93-6 | 99.7% | 25 MG
(R)-Ketorolac is an orally active Cdc42 and Rac1 inhibitor. It inhibits GTPase and alters ovarian cancer cell behaviors critical for invasion and metastasis. It also ameliorates cancer-associated cachexia.
- Inhibits growth factor-dependent activation of Cdc42 and Rac1 in SKOV3ip cells with EC50 values of 2.577 μM for Cdc42 and 0.587 μM for Rac1.
- Decreases numbers and length of filopodia in SKOV3ip cells and reduces their adherence to fibronectin and collagen.
- Ameliorates cancer-associated cachexia and prolongs survival of C26 tumor-bearing mice.
- Prevented C26-induced T-lymphopenia.
Medchemexpress LLC (S)-Ketorolac | 66635-92-5 | 99.3% | 25 MG
(S)-Ketorolac is a nonsteroidal anti-inflammatory agent that exhibits potent COX1 and COX2 enzyme inhibition.
- Target: COX1 and COX2
- Molecular formula: C15H13NO3
- Molecular weight: 255.27
- Appearance: White to off-white solid
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 2 years, -20°C for 1 year
- Solubility in DMSO: 200 mg/mL
Medchemexpress LLC Proguanil (hydrochloride) | 637-32-1 | 99.2% | 25 MG
Proguanil hydrochloride is an antimalarial proagent that is metabolized to its active form, Cycloguanil. It acts as a dihydrofolate reductase (DHFR) inhibitor. It is intended for research use only and not for patient use. The combination of Atovaquone and Proguanil shows in vitro synergy and activity against gametocytes and pre-erythrocytic (hepatic) stages of malaria parasites.
- Metabolized to active form, cycloguanil
- Dihydrofolate reductase (DHFR) inhibitor
- Shows in vitro synergy with atovaquone
- Active against gametocytes and pre-erythrocytic stages of malaria parasites
- Enhances atovaquone effect
- Reversibly inhibits 5-HT3 receptor responses
Medchemexpress LLC Tolazamide | 1156-19-0 | 99.9% | 25 MG
Tolazamide is an orally active sulfonylurea agent that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel. It has anti-diabetic properties, lowering blood glucose and decreasing insulin dose while maintaining adequate metabolic control. Tolazamide is able to improve or normalize hyperglycemia and HbA.
- Inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel.
- Possesses anti-diabetic properties.
- Lowers blood glucose.
- Decreases insulin dose while maintaining adequate metabolic control.
- Improves or normalizes hyperglycemia and HbA.
- Attenuates gluconeogenesis and ketogenesis in preclinical studies.
- Soluble in DMSO (≥ 39 mg/mL).
Medchemexpress LLC Norfloxacin | 70458-96-7 | 98.31% | 10 G
Norfloxacin (MK-0366) is a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria. It operates by inhibiting DNA gyrase and topoisomerase IV, enzymes crucial for bacterial DNA separation, thus hindering cell division. This synthetic chemotherapeutic antibacterial agent is occasionally used for treating common and complicated urinary tract infections.
- Broad-spectrum antibiotic
- Inhibits DNA gyrase and topoisomerase IV
- Active against Gram-positive and Gram-negative bacteria
- Used to treat urinary tract infections