Drug Standards
Medchemexpress LLC Iodixanol | 92339-11-2 | MFCD00867965 | 100.0% | 1 G
Iodixanol is an iodine-containing non-ionic radiocontrast agent used for research purposes. It is noted for exhibiting less kidney toxicity.
- Iodine-containing non-ionic radiocontrast agent
- Exhibits less kidney toxicity
- For research use only
Apexbio Technology LLC Tofacitinib (CP-690550) Citrate(Synonyms: Xeljanz, CP-690550 citrate, Tofacitinib citrate, Tasocitinib citrate, CP690550-10 citrate), 10mg, CAS: 540737-29-9.
Tofacitinib citrate (CP-690550 citrate CAS 540737-29-9) is an inhibitor of Janus kinase 3 (JAK3) a hematopoietic cell-restricted tyrosine kinase that regulates lymphocyte proliferation differentiation survival and apoptosis via intracellular signaling pathways It selectively inhibits JAK3 with an IC50 of approximately 1 nM exhibiting weaker inhibitory activity towards JAK2 and JAK1 (approximately 20-fold and 100-fold weaker respectively) Recent binding affinity studies indicate Ki values of 1 6 nM 21 7 nM and 6 5 nM for JAK1 JAK2 and JAK3 respectively Tofacitinib is widely explored in biomedical research involving immune regulation and inflammatory disorders
AdipoGen Gemcitabine hydrochloride
Chemical. CAS 122111-03-9. Formula C9H11F2N3O4 . HCl. MW 263.20 . 36.46. Synthetic. Widely used antitumor agent in vitro and in vivo. Deoxycytidine analog with cytotoxic effects. Inhibits DNA synthesis and induces apoptosis through inhibition of ribonucleotide reductase R1 and R2. Following the uptake of this prodrug into cells by nucleoside transporters it is phosphorylated to its monodFdCMP, didFdCDP, and triphosphorylateddFdCTP forms by deoxycytidine kinase. dFdCDP and dFdCTP are reported to inhibit the activity of ribonucleotide reductase and impede DNA synthesis and repair mechanisms and induce cell death. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death. By specifically inhibiting growth arrest and DNA damage inducible protein 45 a Gadd45a, a key mediator of active DNA demethylation, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay at concentrations ranging from 34-134nM.
Medchemexpress LLC Tofacitinib impurity 2 | 95.4% | 436.69 | 500 MG
Tofacitinib impurity 2 is an impurity of Tofacitinib. This product is intended for research use only and is not for sale to patients. It is suitable for various laboratory applications requiring an impurity standard.
Medchemexpress LLC Tyloxapol | 25301-02-4 | 10 G
Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, functioning as a surface active stabilizer. It is utilized to induce hyperlipidemia in animals, characterized by high levels of plasma triglycerides and LDL-cholesterol, and reduced HDL-cholesterol. It can increase plasma cholesterol levels by promoting hepatic cholesterol synthesis and disturbing lipolytic enzymes, blocking lipid uptake from circulation.
- Used to induce hyperlipidemia in animals
- Triggers detachment of HEK293 cells
- Induces nuclear fragmentation and apoptotic nuclei
- Increases risk of pulmonary hemorrhage and causes cytotoxicity
- Reduces AChE and MAO enzyme activities in rat plasma and brain
- Leads to reduction in plasma urea, creatinine, and bilirubin
- Appearance: liquid
- Color: colorless to light yellow
Medchemexpress LLC Benzoic acid, 4-hydroxy-, butyl ester | 94-26-8 | MFCD00016478 | 98.9% | 1 ML
Butylparaben is an organic compound that acts as a successful antimicrobial preservative in cosmetics and can also be utilized in active molecule suspensions and as a food flavoring additive. This product is intended for research use only.
- Inhibits orcine fertilization, cleavage, and blastocyst formation rates.
- Induces DNA damage, apoptosis, and autophagy in porcine oocytes.
- Has no systemic toxicity in rats at tested doses.
Medchemexpress LLC Citalopram (hydrobromide) | 59729-32-7 | 99.9% | 100 MG
Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI), with blood-brain barrier permeability. It inhibits 5-HT uptake into synaptosomes and in rabbit blood platelets, exhibiting an antidepressant effect. It also demonstrates concentration-dependent cytotoxicity on the viability of various rat and human neuroblastoma cell lines and human primary Schwann cells.
- Selective serotonin reuptake inhibitor (SSRI)
- Blood-brain barrier permeability
- Inhibits 5-HT uptake
- Antidepressant effect
Medchemexpress LLC Iodixanol | 92339-11-2 | 99.9% | 1 ML
Iodixanol is an iodine-containing non-ionic radiocontrast agent. It exhibits less kidney toxicity.
- Iodine-containing agent
- Non-ionic radiocontrast agent
- Exhibits less kidney toxicity
Medchemexpress LLC Promazine hydrochloride | 53-60-1 | 99.9% | 100 MG
Promazine hydrochloride is an antipsychotic and a dopamine receptor D2 antagonist that inhibits dopaminergic neurotransmission.
- IC50 & Target: D2 Receptor
- Shows KDs of 25, 190, and 8400 nM at the human norepinephrine transporter, serotonin transporter, and dopamine transporter respectively in vitro
- Molecular weight: 320.88
- Formula: C17H21ClN2S
- CAS number: 53-60-1
- Appearance: Solid
- Color: White to off-white
Medchemexpress LLC Butylparaben (standard) | 94-26-8 | 98.9% | 100 MG
Butylparaben (Standard) is the analytical standard of Butylparaben. It is an organic compound used as an antimicrobial preservative in cosmetics, in active molecule suspensions, and as a food flavoring additive. This product is intended for research and analytical applications, particularly as a reference standard in qualitative, quantitative, and methodological research experiments using techniques like HPLC, GC, and MS.
- Analytical standard
- Used as an antimicrobial preservative in cosmetics
- Found in active molecule suspensions
- Used as a food flavoring additive
- Intended for research and analytical applications
- Reference standard for qualitative, quantitative, and methodological research
- Suitable for techniques such as HPLC, GC, and MS
Selleck Chemical LLC SN-38 50mg 86639-52-3
SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Enalaprilat (dihydrate) | 84680-54-6 | 99.6% | 1 ML
Enalaprilat dihydrate (MK-422), the active metabolite of the oral proagent Enalapril, is a potent, competitive, and long-acting angiotensin-converting enzyme (ACE) inhibitor with an IC50 of 1.94 nM. This product is intended for research on hypertension.
- Potent and long-acting ACE inhibitor
- Attenuates IGF-I induced neonatal rat cardiac fibroblast growth in vitro
- Shows significant intraocular pressure (IOP)-lowering effect in rabbits in vivo