Acetylides
Medchemexpress LLC N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | 2112732-01-9 | 519.58 | 25 MG
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs and acts as a click chemistry reagent. This linker contains an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess azide groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Chemscene ChemScene | 4-Chloro-2-(trifluoromethoxy)aniline | 10G | CS-W015037 | 0.98 | 175205-77-3| MFCD00153102 | 211.57
ChemScene | 4-Chloro-2-(trifluoromethoxy)aniline | 10G | CS-W015037 | 0.98 | 175205-77-3| MFCD00153102 | 211.57
Medchemexpress LLC Propargyl-PEG4-amine 1g | 1013921-36-2 | 1 G
Propargyl-PEG4-amine is an alkyne-functional tetraethylene glycol amine used as a linker for bioconjugation and PROTAC synthesis. It provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition and a terminal primary amine for further coupling reactions.
- Provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Contains a tetraethylene glycol spacer to improve solubility and flexibility.
- Offers a terminal primary amine for amide bond formation and other coupling chemistries.
- High purity suitable for synthesis and conjugation (99.7%).
- Molecular weight 231.29 g/mol; formula C11H21NO4.
Medchemexpress LLC Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) | 2358775-67-2 | 95.0% | 100 MG
Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Molecular weight: 350.40
- CAS number: 2358775-67-2
- Purity: 95.0%
- Appearance: Oil
- Color: Off-white to yellow
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | ≥98.0% | 407.50 | C19H37NO8 | 100 MG
Propargyl-PEG8-NH2 is a PEG-based linker reagent used for bioconjugation, including PROTAC and ADC synthesis. It contains a terminal propargyl (alkyne) group and a primary amine, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and amine coupling reactions. The compound is a liquid (colorless to light yellow), with a molecular weight of 407.50 and high purity for research applications.
- Contains terminal alkyne for CuAAC click chemistry.
- Contains primary amine for amide and other coupling reactions.
- PEG8 spacer adds hydrophilicity and flexibility.
- High purity (≥98.0%).
- Available in small and bulk package sizes, including 100 mg.
- Store at 4°C, protect from light, and keep under nitrogen; long-term storage in solvent at -80°C.
STA Pharmaceutical 2'-propargyl G(iBu) amidite | 25 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 25 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 125 mL HDPE
- Pack Size: 25 g
- Net Weight: 25 g
- Gross Weight: 54.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 1,1-dimethylethyl ester | 1807503-80-5 | 95.0% | 250 MG
This compound is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It acts as a click chemistry reagent due to its alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition with azide-containing molecules.
- Application: Can be employed in the synthesis of PROTACs.
- Characteristics: It contains an alkyne group and can participate in copper-catalyzed azide-alkyne cycloaddition.
Aobchem 4-Ethynylaniline | ≥97% | CAS 14235-81-5 | C8H7N | 25g
4-Ethynylaniline | ≥97% | CAS 14235-81-5 | C8H7N | 25g
eMolecules 1072951-56-4 | (5-Bromo-2-(trifluoromethoxy)phenyl)boronic acid | MFCD11504857 | 1g
ChemScene | 2-Fluoro-4-hydroxybenzamide | 250mg | 632274220 | CS-0149671 | 1133122-96-9 | MFCD09999525 | 155.128 | C7H6FNO2
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(C)C#C | 100g | 410166968](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471113.jpg-250.jpg)
eMolecules 1066-54-2 | Ethynyltrimethylsilane | AA Blocks LLC | MFCD00008569 | 98.220 | C5H10Si | 0.000 | C[Si](C)(C)C#C | 100g | 410166968
Ethynyltrimethylsilane | AA Blocks LLC | 1066-54-2 | MFCD00008569 | 98.220 | C5H10Si | 0.000 | C[Si](C)(C)C#C | 100g | 410166968
eMolecules 59608-01-4 | 3-(Pyridin-3-yl)propiolic acid | MFCD02177466 | 1g
Ambeed | 3-(Pyridin-3-yl)propiolic acid | 1g | 588343019 | A625596 | 59608-01-4 | MFCD02177466 | 147.133 | C8H5NO2
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![eMolecules 22287-32-7 | (BICYCLO[1.1.1]PENT-1-YL)METHANOL | AstaTech | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 0.25g | 624132233](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000158771.jpg-250.jpg)
eMolecules 22287-32-7 | (BICYCLO[1.1.1]PENT-1-YL)METHANOL | AstaTech | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 0.25g | 624132233
(BICYCLO[1.1.1]PENT-1-YL)METHANOL | AstaTech | 22287-32-7 | MFCD28040494 | 98.145 | C6H10O | 95.000 | OCC12CC(C1)C2 | 0.25g | 624132233
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | MFCD28334507 | >98.0% | 407.50 g/mol | C19H37NO8 | 10 MG
Propargyl-PEG8-NH2 is an alkyne-terminated polyethylene glycol (PEG8) amine linker used for bioconjugation and linker synthesis. It provides a terminal alkyne for click chemistry and a primary amine for further derivatization, with a PEG8 spacer to improve solubility and spacing between conjugated moieties.
- Provides a terminal alkyne group for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Contains a primary amine for amide formation and further functionalization.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High chemical purity suitable for research applications.
- Colorless to light yellow liquid, convenient for solution-phase coupling reactions.
- Commonly used in PROTAC, ADC, and general bioconjugation workflows.
Medchemexpress LLC Tert-butyl N-(5-hydroxypentyl)carbamate | 75178-90-4 | MFCD01862955 | >97.0% | 203.28 g·mol⁻1 | C10H21NO3 | 1 G
5-(Boc-amino)-1-pentanol is a Boc-protected 5-aminopentanol used as a versatile intermediate and linker in organic and medicinal chemistry. It contains a tert-butoxycarbonyl protected amine and a primary alcohol, enabling selective deprotection and further functionalization for synthesis of peptides, small molecules, and conjugates.
- Boc-protected amine enables selective deprotection workflows.
- Primary alcohol allows further derivatization and coupling reactions.
- High purity suitable for synthetic and medicinal chemistry applications.
- Defined storage stability in solvent and bulk formats.
- Useful as a linker for conjugation and building-block synthesis.
Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | ≥97.0% | 348.39 g/mol | C16H28O8 | 250 MG
Propargyl-PEG6-acid is a PEG-based linker and click chemistry reagent containing a terminal alkyne. It is used as a linker in PROTAC and ADC synthesis and for copper-catalyzed azide-alkyne cycloaddition (CuAAc) bioconjugation reactions.
- cleavable PEG6 linker suitable for PROTAC and ADC synthesis
- contains a terminal propargyl (alkyne) group for click chemistry
- high purity (≥97.0% by NMR) suitable for research applications
- molecular weight 348.39 g/mol, molecular formula C16H28O8
- storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month)