Acetylides
Medchemexpress LLC Propargyl-PEG4-acid | 1415800-32-6 | 97.0% | 500 MG
Propargyl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of BTK-IAP PROTACs Ibrutinib-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells.
- PEG-based PROTAC linker
- Can be used in the synthesis of BTK-IAP PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups
![Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202866.png-250.jpg)
Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | MFCD19160595 | 99.6% | 143.18 g/mol | C7H13NO2 | 250 MG
Propargyl-PEG2-amine is a PEG-based propargyl-functionalized amine used as a short spacer linker for bioconjugation. It provides a terminal alkyne for click chemistry and a primary amine for conjugation, making it suitable for linker synthesis and medicinal chemistry research.
- Short PEG2 spacer with terminal alkyne for click chemistry.
- Primary amine for facile conjugation to activated esters and similar chemistries.
- High purity suitable for research-grade applications.
- Compact 250 MG packaging for laboratory-scale experiments.
- Soluble in common organic solvents used in synthesis and bioconjugation.
Medchemexpress LLC (2,5-dioxopyrrolidin-1-yl) hex-5-ynoate | 906564-59-8 | MFCD28898858 | 97.0% | 209.20 g/mol | C10H11NO4 | 50 MG
Propargyl-C2-NHS ester is an alkyne-containing N-hydroxysuccinimide (NHS) ester used for bioconjugation. It serves as a non-cleavable linker and a click-chemistry reagent enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-bearing molecules.
- Contains a propargyl (alkyne) group for CuAAC reactions.
- Designed for antibody conjugation and general bioconjugation.
- Molecular formula C10H11NO4; molecular weight 209.20 g/mol.
- High purity: 97.0%.
- Stored at -20°C in pure form; available in small pack sizes for research use.
Medchemexpress LLC Propargyl-PEG2-amine | 944561-44-8 | 99.6% | 143.18 g/mol | C7H13NO2 | 5 G
Propargyl-PEG2-amine is a short polyethylene glycol (PEG2) linker with a terminal propargyl (alkyne) group and a primary amine, used to introduce alkyne handles for click chemistry and bioconjugation.
- Short PEG2 spacer with terminal alkyne and primary amine.
- Suitable for click chemistry (CuAAC) and other bioconjugation reactions.
- Molecular weight 143.18 g/mol; formula C7H13NO2.
- Offered as a 5 g powder; store at 4°C, protect from light, under nitrogen.
- CAS number 944561-44-8 for unambiguous identification.
Medchemexpress LLC VQW-765 | 669770-29-0 | 99.6% | 294.40 | 100 MG
VQW-765 | 669770-29-0 | 99.6% | 294.40 | 100 MG
eMolecules 2949-26-0 | Naphthylene-2-acetylene | Oakwood Chemicals | MFCD00870424 | 152.196 | C12H8 | 98.000 | C#Cc1ccc2ccccc2c1 | 1g | 486555901
Naphthylene-2-acetylene | Oakwood Chemicals | 2949-26-0 | MFCD00870424 | 152.196 | C12H8 | 98.000 | C#Cc1ccc2ccccc2c1 | 1g | 486555901
Medchemexpress LLC (S)-VQW-765 ((S)-AQW-051) | 98.0% | 294.39 | 5 MG
(S)-VQW-765 ((S)-AQW-051) is an orally active, selective, and effective α7 nicotinic ACh receptor (nAChR) partial agonist. It has potential applications in cognitive disorders related to neurological diseases, such as Alzheimer's disease or schizophrenia.
- Orally active, selective, and effective α7 nAChR partial agonist
- Potential applications in cognitive disorders
- Suitable for neurological diseases like Alzheimer's or schizophrenia
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | MFCD01346226 | 100.0% | 1083.12 | C54H63FN8O15 | 100 MG
Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugates (ADCs) that links an ADC linker to the DNA topoisomerase I inhibitor DXd and provides a propargyl handle for bioorthogonal conjugation.
- Molecular formula: C54H63FN8O15
- Molecular weight: 1083.12
- Cas number: 2762518-94-3
- Purity: 99.99%
- Appearance: solid, off-white to light yellow
- Storage: 4°C sealed, away from moisture; in solvent: -80°C for 6 months, -20°C for 1 month
- Package size: available in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg; larger sizes available by quote
eMolecules 1072951-56-4 | (5-Bromo-2-(trifluoromethoxy)phenyl)boronic acid | MFCD11504857 | 1g
ChemScene | 2-Fluoro-4-hydroxybenzamide | 250mg | 632274220 | CS-0149671 | 1133122-96-9 | MFCD09999525 | 155.128 | C7H6FNO2
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Medchemexpress LLC Propargyl-PEG5-Br | 1287660-83-6 | 339.22 | 1 G
Propargyl-PEG5-Br is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs and functions as a click chemistry reagent. It contains an Alkyne group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Enables synthesis of PROTACs
- Functions as a click chemistry reagent
- Features an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules
- Supports development of PROTACs for target protein degradation
Medchemexpress LLC Propargyl-PEG6-alcohol | 944560-99-0 | 97.0% | 1 G
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Used in the synthesis of proteolysis targeting chimeras (PROTACs)
- Contains an alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Propargyl-PEG10-acid | 2055022-18-7 | 98.0% | 524.60 | 250 MG
Propargyl-PEG10-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. It functions as a click chemistry reagent, utilizing an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing azide groups.
- PEG derivative
- Contains a propargyl group
- Features a terminal carboxylic acid
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition with azide groups
Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | 489.51 g/mol | C22H35NO11 | 250 MG
Propargyl-PEG7-NHS ester is an amine-reactive PEG-based linker used for bioconjugation, antibody-drug conjugate (ADC) and PROTAC synthesis, and click-chemistry applications. The reagent contains a terminal propargyl (alkyne) group and an N-hydroxysuccinimide (NHS) ester for coupling to primary amines.
- Amine-reactive NHS ester for efficient coupling to primary amines.
- Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- PEG7 spacer improves solubility and provides flexibility between conjugated moieties.
- Available in small laboratory pack sizes for research use.