Acetylides
Medchemexpress LLC Propargyl-PEG24-amine | 98.0% | 1112.34 | 25 MG
Propargyl-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Peg-based protac linker
- Used in the synthesis of protacs
- Click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Propargyl-PEG1-Boc | 488150-84-1 | 97.0% | 184.23 | 250 MG
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs are composed of two different ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets a specific protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Alkyl/ether-based PROTAC linker
- Used in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Utilizes the ubiquitin-proteasome system for targeted protein degradation
Medchemexpress LLC Propargyl-PEG10-acid | 2055022-18-7 | 98.0% | 524.60 | 100 MG
Propargyl-PEG10-acid is a PEG derivative featuring a propargyl group and a terminal carboxylic acid. It serves as a click chemistry reagent, utilizing an Alkyne group to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Azide groups. For research use only.
- PEG derivative with propargyl and terminal carboxylic acid groups
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Reacts with molecules possessing Azide groups
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | >98.0% | 392.44 g/mol | C18H32O9 | 25 MG
Propargyl-PEG7-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group used for click chemistry, PROTAC assembly, and antibody-drug conjugate (ADC) synthesis. It is supplied as a light yellow liquid of high purity suitable for research bioconjugation workflows.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Suitable for PROTAC and ADC linker synthesis.
- High purity (≥98.0%), compatible with analytical workflows.
- Light yellow liquid form, convenient for solution-phase conjugation.
- Available in small-scale and bulk pack sizes for synthesis needs.
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 30 mL Glass (28-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 50.1 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
eMolecules 106-96-7 | Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 100g | 537712117
Propargyl bromide (80% wt.in toluene) contains 0.3% magnesium oxide as stabilizer | Oakwood Chemical | 106-96-7211.102 | C10H11Br | 0.000 | BrCC#C.Cc1ccccc1 | 100g | 537712117
Medchemexpress LLC Propargyl-PEG3-methane | 89635-82-5 | 98.0% | 202.25 | 10 G
Propargyl-PEG3-methane is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- PEG-based PROTAC linker.
- Utilized in the synthesis of PROTACs.
- Click chemistry reagent.
- Contains an alkyne group.
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing azide groups.
- Selectively degrades target proteins by exploiting the intracellular ubiquitin-proteasome system.
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | >=97.0% | 290.31 | 100 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This compound is also a click chemistry reagent, featuring an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker for PROTAC synthesis.
- Click chemistry reagent.
- Contains an Alkyne group.
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide groups.
Medchemexpress LLC Propargyl-PEG1-Boc | 488150-84-1 | 97.0% | 184.23 | 100 MG
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker, a click chemistry reagent, utilized in the synthesis of PROTACs. It contains an Alkyne group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Azide groups.
- Used as a PROTAC linker for synthesizing PROTACs.
- Functions as a click chemistry reagent.
- Contains an Alkyne group for CuAAc reactions.
- Enables reactions with molecules possessing Azide groups.
- Supports the PROTAC mechanism of action, which involves the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
eMolecules 1092461-24-9 | 5-Chloro-2-(trifluoromethoxy)phenol | Apollo Scientific | MFCD11519363 | 212.550 | C7H4ClF3O2 | 97.000 | Oc1cc(Cl)ccc1OC(F)(F)F | 1g | 562454745
5-Chloro-2-(trifluoromethoxy)phenol | Apollo Scientific | 1092461-24-9 | MFCD11519363 | 212.550 | C7H4ClF3O2 | 97.000 | Oc1cc(Cl)ccc1OC(F)(F)F | 1g | 562454745
Medchemexpress LLC Propargyl-PEG5-NHS ester | 1393330-40-9 | 98.0% | 401.41 g/mol | C18H27NO9 | 250 MG
Propargyl-PEG5-NHS ester is an alkyne-terminated, amine-reactive PEG5 NHS ester used for bioconjugation and click chemistry. The NHS ester reacts with primary amines to form stable amide bonds, while the propargyl (alkyne) group enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it suitable for linker incorporation in antibody-drug conjugates and PROTAC synthesis.
- Amine-reactive NHS ester for stable amide formation.
- Alkyne (propargyl) handle for copper-catalyzed click chemistry.
- PEG5 spacer provides hydrophilicity and conformational flexibility.
- High purity suitable for research-grade bioconjugation.
- Available in milligram to gram pack sizes for method development.
![Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | 99.6% | 143.18 | C7H13NO2 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203119.png-250.jpg)
Medchemexpress LLC Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 944561-44-8 | 99.6% | 143.18 | C7H13NO2 | 1 G
Propargyl-PEG2-amine is a short PEG2-based linker containing a terminal propargyl (alkyne) group and a primary amine for bioconjugation. It is supplied as a colorless to light yellow liquid and is used as an ADC linker, PROTAC linker, and general crosslinking building block for click-type chemistries.
- Contains a terminal propargyl functional group for click reactions.
- Provides a short, flexible PEG2 spacer between functional groups.
- Features a primary amine for coupling to carboxyl or activated esters.
- Supplied as a colorless to light yellow liquid for easy handling.
- Molecular weight 143.18 and CAS number 944561-44-8 for unambiguous identification.
Medchemexpress LLC Propargyl-PEG6-alcohol | 944560-99-0 | 97.0% | 5 G
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group, and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group for CuAAc reactions
- Can react with azide-containing molecules