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1

Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 g/mol | C20H36O10 | 1 G

Propargyl-PEG8-acid is a polyethylene glycol (PEG) based linker bearing a terminal propargyl (alkyne) group and a carboxylic acid, used for conjugation in PROTAC and antibody-drug conjugate (ADC) synthesis.

  • Contains a terminal propargyl alkyne for click chemistry.
  • Provides a carboxylic acid handle for amide coupling.
  • Approximate molecular weight 436.49 g/mol.
  • High purity (98.0%) suitable for research applications.
  • Available in multiple pack sizes, including 1 G for lab-scale use.

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2

Medchemexpress LLC 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoic acid | 1347760-82-0 | MFCD22201521 | 99.1% | 216.23 g/mol | C10H16O5 | 1 G

Propargyl-PEG3-acid is a PEG-based bifunctional linker bearing a terminal propargyl (alkyne) group and a carboxylic acid handle, used for click chemistry and conjugation in small-molecule and bioconjugate synthesis.

  • Terminal alkyne functional group for copper-catalyzed azide-alkyne cycloaddition
  • Carboxylic acid end group for amide coupling and further derivatization
  • Three-unit PEG spacer imparts solubility and flexibility
  • High reported purity suitable for synthetic applications
  • Available in 1 g pack for small-scale synthesis

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3

Medchemexpress LLC Bis-PEG1-C-PEG1-CH2COOH | 2358775-67-2 | MFCD22381072 | 95.0% | 350.40 | C16H30O8 | 5 MG

Bis-PEG1-C-PEG1-CH2COOH is a PEG-based bifunctional linker bearing a terminal carboxylic acid; it serves as a building block for the synthesis of PROTACs and other conjugates. The material is supplied as an off-white to yellow oil, and is typically offered at research-grade purity for small-scale synthetic work.

  • PEG-based bifunctional linker for PROTAC and conjugate synthesis.
  • Terminal carboxylic acid enables standard amide or ester coupling reactions.
  • Low molecular weight building block (MW 350.4) for modular design.
  • Supplied as an off-white to yellow oil suitable for solution-phase synthesis.
  • High purity appropriate for research applications (95.0%).
  • Available in small pack sizes for screening and library synthesis.

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4

Medchemexpress LLC Propargyl-PEG5-acid | 1245823-51-1 | 98.0% | 304.34 g/mol | C14H24O7 | 1 G

Propargyl-PEG5-acid is a polyethylene glycol-based linker with a terminal propargyl (alkyne) group and a terminal carboxylic acid. It is used as a non-cleavable PEG spacer in bioconjugation, including antibody-drug conjugate and PROTAC synthesis, and as a reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).

  • Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition.
  • Terminal carboxylic acid allows amide bond formation with primary amines.
  • Five-unit PEG spacer improves solubility and reduces steric hindrance.
  • High purity (98.0%) suitable for bioconjugation.
  • Applicable to ADC, PROTAC, and general linker development workflows.

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5

Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 g/mol | C10H16O5 | 5 G

Propargyl-PEG3-acid is a PEG-based bifunctional linker bearing a terminal propargyl (alkyne) group and a carboxylic acid. It is used in bioconjugation and medicinal chemistry applications such as click chemistry and PROTAC or ADC linker construction.

  • Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition
  • Three-unit PEG spacer improves solubility and flexibility
  • Carboxylic acid functionality enables standard coupling chemistries
  • High purity (99.14%) and liquid form, colorless to light yellow
  • Available in multiple sizes, including a 5 g package; recommended storage: -20°C for long-term stability

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6

Apexbio Technology LLC Propargyl-PEG2-acid 1859379-85-3 5g

Propargyl-PEG2-acid (CAS 1859379-85-3) is a polyethylene glycol (PEG)-based small molecule featuring a terminal propargyl (alkyne) group and a carboxylic acid moiety The alkyne functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions commonly referred to as click chemistry This enables site-specific conjugation to azide-containing molecules for the synthesis of bioconjugates such as antibody-drug conjugates (ADCs) labeling probes or other functionalized biomolecules Its PEG2 spacer increases solubility and flexibility supporting its application in biomedical research requiring stable and efficient heterobifunctional linkers

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7

Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 95.0% | 392.44 | C18H32O9 | 100 MG

Propargyl-PEG7-acid is a PEG7-based linker bearing a terminal propargyl (alkyne) group used for assembling PROTACs, synthesizing antibody-drug conjugates, and performing copper-catalyzed azide-alkyne click reactions.

  • Terminal alkyne for CuAAC click chemistry
  • PEG7 spacer improves solubility and linker flexibility
  • Suitable for PROTAC and ADC linker synthesis
  • Available in multiple pack sizes for scalable use

ENCOMPASS_PREFERRED
8

Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 | C10H16O5 | 250 MG

Propargyl-PEG3-acid is a PEG-based bifunctional linker featuring a terminal propargyl (alkyne) group and a carboxylic acid; it is used as a non-cleavable three-unit PEG linker for antibody-drug conjugates and as a PEG linker for PROTACs, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.

  • Non-cleavable three-unit PEG linker suitable for ADC and PROTAC synthesis.
  • Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition for conjugation to azide-containing molecules.
  • High purity appropriate for research-scale bioconjugation workflows.
  • Available in multiple pack sizes to support small-scale and larger preparative work.

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9

Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG

Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.

  • Cleavable PEG linker suitable for PROTAC and ADC synthesis.
  • Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
  • High purity supports reliable coupling reactions.
  • Stable as a dry powder when stored under inert atmosphere at low temperature.
  • Available in small research packs for medicinal chemistry use.

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10

Medchemexpress LLC Propargyl-peg6-acid | 1951438-84-8 | 348.39 g/mol | C16H28O8 | 50 MG

Propargyl-PEG6-acid is a PEG6-based linker and click-chemistry reagent containing a terminal propargyl (alkyne) group and a carboxylic acid. It is used to introduce a PEG6 spacer in the synthesis of PROTACs and antibody-drug conjugates (ADCs) and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation.

  • Used as PEG6 spacer in PROTAC and ADC synthesis.
  • Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Molecular weight 348.39 g/mol; formula C16H28O8.
  • CAS number 1951438-84-8 for unambiguous identification.
  • Storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).

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11

Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | ≥98.0% | 392.44 | C18H32O9 | 250 MG

Propargyl-PEG7-acid is a PEG-based linker and click chemistry reagent containing a terminal alkyne that enables copper-catalyzed azide-alkyne cycloaddition. It is used as a PROTAC linker and as a cleavable linker in antibody-drug conjugate synthesis.

  • Contains terminal alkyne suitable for CuAAc
  • PEG7 spacer provides solubility and conformational flexibility
  • Applicable as a cleavable linker for ADC synthesis
  • High purity: ≥98.0% (NMR)
  • Available in small-scale pack sizes for research use

ENCOMPASS_PREFERRED
12

Medchemexpress LLC 4,7,10,13,16-pentaoxanonadec-18-ynoic acid | 1245823-51-1 | MFCD22201536 | ≥98.0% | 304.34 g/mol | C14H24O7 | 1 G

Propargyl-PEG5-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group and a free carboxylic acid. It is used as a click-chemistry reagent and as a non-cleavable five-unit PEG spacer for bioconjugation workflows such as PEGylation and antibody-drug conjugate linker synthesis. The material is supplied as a colorless to light-yellow liquid with ≥98.0% purity and is intended for research use; store protected from light at -20°C, or in solution at -80°C for longer-term storage.

  • Contains terminal propargyl alkyne for copper-catalyzed azide-alkyne cycloaddition.
  • Five-unit PEG spacer improves solubility and reduces aggregation.
  • Free carboxylic acid enables conjugation through standard activation chemistries.
  • High purity (≥98.0%) for reproducible research results.
  • Colorless to light-yellow liquid; stable when stored protected from light at -20°C.
  • Intended for research use only; not validated for clinical applications.

ENCOMPASS_PREFERRED
13

Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | >98.0% | 392.44 g/mol | C18H32O9 | 25 MG

Propargyl-PEG7-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group used for click chemistry, PROTAC assembly, and antibody-drug conjugate (ADC) synthesis. It is supplied as a light yellow liquid of high purity suitable for research bioconjugation workflows.

  • Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Suitable for PROTAC and ADC linker synthesis.
  • High purity (≥98.0%), compatible with analytical workflows.
  • Light yellow liquid form, convenient for solution-phase conjugation.
  • Available in small-scale and bulk pack sizes for synthesis needs.

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14

Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | 348.39 g·mol⁻1 | C16H28O8 | 100 MG

Propargyl-PEG6-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group, used as a click-chemistry reagent and as a linker in the synthesis of PROTACs and antibody-drug conjugates. The PEG6 spacer increases hydrophilicity and enables conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC).

  • Contains a terminal propargyl (alkyne) functional group.
  • Suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Used in synthesis of PROTACs and antibody-drug conjugates.
  • PEG6 spacer provides hydrophilicity and improved solubility.
  • Storage recommendations: pure form refrigerated or frozen for long-term stability; store solutions frozen.

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15

Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | ≥97.0% | 348.39 g/mol | C16H28O8 | 250 MG

Propargyl-PEG6-acid is a PEG-based linker and click chemistry reagent containing a terminal alkyne. It is used as a linker in PROTAC and ADC synthesis and for copper-catalyzed azide-alkyne cycloaddition (CuAAc) bioconjugation reactions.

  • cleavable PEG6 linker suitable for PROTAC and ADC synthesis
  • contains a terminal propargyl (alkyne) group for click chemistry
  • high purity (≥97.0% by NMR) suitable for research applications
  • molecular weight 348.39 g/mol, molecular formula C16H28O8
  • storage: pure form -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month)

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