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Organic compounds that contain a carbon - carbon triple bond substituted with a metal in the following structure: MC≡CM, where C is carbon and M is a metal.
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Propargyl-PEG3-methane is a PEG-based PROTAC linker, designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It functions as a versatile click chemistry reagent, facilitating various bioconjugation and labeling applications.
PEG-based PROTAC linker
Utilized in the synthesis of PROTACs
Functions as a click chemistry reagent
Facilitates bioconjugation and labeling
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ViaTag 740/765 Haloalkane Ligand is a bright fluorescent ligand for the HaloTag self-labeling protein tag Near-infrared fluorescent ViaTag 740/765 is cell impermeant and has an excitation/emission of 742/767 nm 30 uL of 1000X
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Propargyl-PEG7-NHS ester is an alkyne-functional PEG7 N-hydroxysuccinimide (NHS) ester used as a bifunctional linker for bioconjugation. It couples to primary amines via NHS chemistry and provides a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition, making it suitable for ADC, PROTAC, and general labeling applications.
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O-propargyl-puromycin (OPP CAS 1416561-90-4) is an alkyne-functionalized derivative of puromycin commonly utilized to detect and quantify newly synthesized proteins It incorporates into nascent polypeptides by acting as a translation terminator covalently attaching to their C-terminal ends Subsequent detection occurs through azide-alkyne cycloaddition under copper(I) catalysis facilitating visualization or isolation of actively produced proteins In cellular and animal models OPP labeling enables measurement of global protein synthesis rates and assessment of responses to various stimuli or stress conditions contributing significantly to proteomics and cell biology research
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Propargyl-PEG2-acid (CAS 1859379-85-3) is a polyethylene glycol (PEG)-based small molecule featuring a terminal propargyl (alkyne) group and a carboxylic acid moiety The alkyne functionality facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions commonly referred to as click chemistry This enables site-specific conjugation to azide-containing molecules for the synthesis of bioconjugates such as antibody-drug conjugates (ADCs) labeling probes or other functionalized biomolecules Its PEG2 spacer increases solubility and flexibility supporting its application in biomedical research requiring stable and efficient heterobifunctional linkers
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