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Acetylides

Organic compounds that contain a carbon - carbon triple bond substituted with a metal in the following structure: MC≡CM, where C is carbon and M is a metal.

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1

eMolecules​ Chem-Impex Copper(II) sulfate pentahydrate 100kg 386903341 30243 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

Chem-Impex Copper(II) sulfate pentahydrate 100kg 386903341 30243 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

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2

eMolecules​ Chem-Impex Copper(II) sulfate pentahydrate 2 5kg 322127335 30243 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

Chem-Impex Copper(II) sulfate pentahydrate 2 5kg 322127335 30243 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

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3

eMolecules​ Chem-Impex Copper(II) sulfate pentahydrate 2 5kg 603112431 35293 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

Chem-Impex Copper(II) sulfate pentahydrate 2 5kg 603112431 35293 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

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4

eMolecules​ Oakwood Chemicals Copper(II) sulfate pentahydrate ACS reagent 2 5kg 480169046 492479 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

Oakwood Chemicals Copper(II) sulfate pentahydrate ACS reagent 2 5kg 480169046 492479 0 000 7758-99-8 MFCD00149681 249 680 CuH10O9S

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5

Medchemexpress LLC Propargyl-PEG8-NHS ester | 2182601-74-5 | MFCD31536764 | 95.0% | 533.57 | C24H39NO12 | 50 MG

Propargyl-PEG8-NHS ester is an alkyne-terminated PEG8 N-hydroxysuccinimidyl (NHS) ester used as an activated linker for amine coupling and copper-catalyzed azide-alkyne cycloaddition (click chemistry).

  • Provides an activated NHS ester for efficient amine coupling.
  • Contains a terminal propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • PEG8 spacer improves solubility and reduces steric hindrance.
  • Suitable for linker and conjugation synthesis such as ADC and PROTAC linker construction.
  • Viscous liquid physical form with recommended cold storage for stability.

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6

Medchemexpress LLC 3-Butynyl p-toluenesulfonate | 23418-85-1 | MFCD00041687 | 98.7% | 224.28 g/mol | C11H12O3S | 10 G

An alkyne-bearing p-toluenesulfonate ester used as a click-chemistry reagent and cleavable linker for antibody-drug conjugate synthesis; it undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC).

  • Reacts in copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Molecular formula C11H12O3S; molecular weight 224.28 g/mol.
  • CAS number 23418-85-1.
  • Purity typically 98.7%.
  • Appearance colorless to light yellow liquid.
  • Available in 1 g, 5 g, 10 g, and 50 g package sizes.

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7

Medchemexpress LLC Bis-propargyl-PEG8 10mg | 1092554-87-4 | 10 MG

Bis-propargyl-PEG8 is a PEG8-based bifunctional linker bearing terminal propargyl (alkyne) groups, used as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in PROTAC and bioconjugation synthesis.

  • Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Suitable for PROTAC linker construction and bioconjugation chemistry.
  • PEG8 spacer improves solubility and provides flexible linkage length.
  • Contains two terminal alkynes for dual conjugation sites.
  • Supplied in small, pre-weighed mg quantities for research applications.

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8

Medchemexpress LLC Propargyl-PEG12-OH 250mg | 1036204-61-1 | 584.69 | C27H52O13 | 250 MG

Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs Propargyl-PEG12-OH is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups

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9

Medchemexpress LLC Bis-propargyl-PEG8 250mg | 1092554-87-4 | 250 MG

Bis-propargyl-PEG8 is a PEG-based PROTAC linker with two terminal propargyl (alkyne) groups used as a click-chemistry reagent to join azide-bearing fragments via copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is supplied in small-scale laboratory pack sizes for research use.

  • Contains two terminal alkyne (propargyl) groups.
  • Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • PEG8 spacer provides a flexible, hydrophilic linker.
  • Supplied in multiple small laboratory pack sizes.
  • Molecular formula C22H38O9; molecular weight 446.53.

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10

Medchemexpress LLC Propargyl-PEG4-amine 1g | 1013921-36-2 | 1 G

Propargyl-PEG4-amine is an alkyne-functional tetraethylene glycol amine used as a linker for bioconjugation and PROTAC synthesis. It provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition and a terminal primary amine for further coupling reactions.

  • Provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
  • Contains a tetraethylene glycol spacer to improve solubility and flexibility.
  • Offers a terminal primary amine for amide bond formation and other coupling chemistries.
  • High purity suitable for synthesis and conjugation (99.7%).
  • Molecular weight 231.29 g/mol; formula C11H21NO4.

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11

Medchemexpress LLC Propargyl-PEG2-bromi 250mg

Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1] Propargyl-PEG2-bromide is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups

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12

Medchemexpress LLC Propargyl-PEG2-bromi 100mg

Propargyl-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1] Propargyl-PEG2-bromide is a click chemistry reagent it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups

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13

Medchemexpress LLC Propargyl-PEG8-bromide | 2055046-25-6 | 471.38 | C19H35BrO8 | 100 MG

Propargyl-PEG8-bromide is a PEG-based linker reagent containing a terminal propargyl (alkyne) group and a terminal bromide. It is used for bioconjugation and linker synthesis, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and functioning as a non-cleavable ADC and PROTAC linker.

  • Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition.
  • Provides an eight-unit polyethylene glycol spacer for flexibility and solubility.
  • Has a terminal bromide for nucleophilic substitution or further functionalization.
  • Suitable for ADC and PROTAC linker synthesis and click chemistry applications.
  • Available in small-scale laboratory quantities for research use.

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14

Medchemexpress LLC Propargyl-PEG5-acid | 1245823-51-1 | 98.0% | 304.34 g/mol | C14H24O7 | 1 G

Propargyl-PEG5-acid is a polyethylene glycol-based linker with a terminal propargyl (alkyne) group and a terminal carboxylic acid. It is used as a non-cleavable PEG spacer in bioconjugation, including antibody-drug conjugate and PROTAC synthesis, and as a reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).

  • Terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition.
  • Terminal carboxylic acid allows amide bond formation with primary amines.
  • Five-unit PEG spacer improves solubility and reduces steric hindrance.
  • High purity (98.0%) suitable for bioconjugation.
  • Applicable to ADC, PROTAC, and general linker development workflows.

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15

Medchemexpress LLC Propargyl-PEG6-acid | 1951438-84-8 | 348.39 g·mol⁻1 | C16H28O8 | 100 MG

Propargyl-PEG6-acid is a PEG-based linker bearing a terminal propargyl (alkyne) group, used as a click-chemistry reagent and as a linker in the synthesis of PROTACs and antibody-drug conjugates. The PEG6 spacer increases hydrophilicity and enables conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC).

  • Contains a terminal propargyl (alkyne) functional group.
  • Suitable for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
  • Used in synthesis of PROTACs and antibody-drug conjugates.
  • PEG6 spacer provides hydrophilicity and improved solubility.
  • Storage recommendations: pure form refrigerated or frozen for long-term stability; store solutions frozen.

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