Hydrochlorides
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 25 MG
VU-1545 is a potent metabotropic glutamate receptor 5 (mGluR5) positive allosteric modulator (PAM) with a Ki of 156 nM and an EC50 of 9.6 nM. It promotes AKT activation, efficiently doing so at concentrations as low as 0.1 and 1.0 μM. Studies have shown that VU-1545 at 10 and 100 μM promotes Akt phosphorylation. This compound is used for research purposes and is not intended for patient use.
- Potent mGluR5 positive allosteric modulator
- Ki of 156 nM for mGluR5
- EC50 of 9.6 nM for mGluR5
- Promotes AKT activation in neuronal cells
- Efficiently promotes Akt phosphorylation at 10.0 μM and 100.0 μM
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 50 MG
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM). It exhibits a Ki of 156 nM and an EC50 of 9.6 nM. This compound promotes AKT activation at concentrations of 0.1 and 1.0 μM and is intended for research use only.
- Functions as a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM).
- Demonstrates a Ki of 156 nM and an EC50 of 9.6 nM.
- Promotes AKT activation.
- Promotes Akt phosphorylation in neuronal cells.
- Solid appearance, light yellow to yellow color.
- Powder storage: -20°C for 3 years, 4°C for 2 years.
- In solvent storage: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 100 MG
VU-1545 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.
- Promotes AKT activation at concentrations of 0.1 and 1.0 μM.
- Neuroprotective in a mouse model of Huntington's disease.
- For research use only, not for sale to patients.