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Filtered Search Results
Apexbio Technology LLC AZ 628 878739-06-1 10mg
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AZ 628 (CAS 878739-06-1) is a potent inhibitor of RAF kinases targeting BRAF c-RAF-1 and the mutant BRAFV600E with reported IC50 values of 105 nM 34 nM and 29 nM respectively The compound exerts its activity by occupying the ATP-binding site of RAF kinases thereby blocking CRAF activation it also affects other tyrosine kinases such as DDR2 VEGFR2 Lyn Flt1 and FMS AZ 628 disrupts the RAS-RAF-MEK-ERK (MAPK) signaling cascade influencing cellular responses including proliferation and apoptosis In preclinical studies AZ 628 inhibits growth and induces apoptosis in BRAF V600E-mutant melanoma and colorectal cancer cell lines and demonstrates anti-angiogenic effects via VEGFR2 inhibition
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Aobchem AOBCHEM
5000866267 1- 2-CHLORO-6- TRIFLUOROMETHYL
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370688 AZ-23 10MM 1ML
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AARON CHEMICALS LLC DIPHENYLIODONIUM TRIFLUOROMETH
NC3827149 DIPHENYLIODONIUM TRIFLUOROMETH
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Aobchem AOBCHEM
5000862100 2-CHLORO-6- TRIFLUOROMETHYL BE
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Aobchem AOBCHEM
5000864096 1 3-DIMETHYL-5- TRIFLUOROMETHY
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Medchemexpress LLC cyclo(RLsKDK) | 1975145-82-4 | 98.85% | 727.85 | 1 MG
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cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8, demonstrating an IC50 value of 182 nM. This compound holds potential applications in the treatment of inflammatory diseases and various cancers.
- Specific inhibitor of metalloproteinase ADAM8 (IC50 182 nM).
- Potential applications in inflammatory diseases and cancer research.
- Promotes ADAM8 activation and CD23 shedding.
- Increases activity of pro-ADAM8.
- Induces ERK1/2 phosphorylation in Panc1_ctrl and Panc1_A8 cells.
- Reduces cell invasion in a dose-dependent manner.
- Significantly reduces tumor load and improves survival in PDAC mouse models.
- Decreases soluble ADAM8 content, pERK1/2 activation, and PDAC metastasis.
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Ambeed AMBEED
5000866478 2-CHLORO-6-TRIFLUOROMETHYL 5GR
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Ambeed AMBEED
5000869467 1-DIFLUOROMETHYL-4-IODO-1H 1GR
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Aobchem AOBCHEM
5000865259 2-FLUORO-6- 2 2 2-TRIFLUOROETH
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Selleck Chemical LLC CY-09
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CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself It is tested against the five major cytochrome P450 enzymes 1A2 2C9 2C19 2D6 and 3A4 with half maximal inhibitory concentration (IC50) values of 18 9 8 18 50 50 and 26 0 M respectively
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Aobchem AOBCHEM
5000865066 3 5-DIBROMO-6-METHOXY-2-PYRIDI
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Aobchem AOBCHEM
5000865165 2-CHLORO-5- TRIFLUOROMETHYL NI
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Aobchem AOBCHEM
5000865264 3-BROMO-4- 4- TRIFLUOROMETHYL
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eMolecules 261635-83-0 | 6-Chloro-2-(trifluoromethyl)nicotinic acid | ChemScene | MFCD11840271 | 225.550 | C7H3ClF3NO2 | 98.000 | OC(=O)c1ccc(Cl)nc1C(F)(F)F | 15g | 894452939
6-Chloro-2-(trifluoromethyl)nicotinic acid | ChemScene | 261635-83-0 | MFCD11840271 | 225.550 | C7H3ClF3NO2 | 98.000 | OC(=O)c1ccc(Cl)nc1C(F)(F)F | 15g | 894452939
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