Organofluorides

Medchemexpress LLC Cyclo(CLLFVY) | 1446322-73-1 | 99.37% | 738.94 | 1 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 values of 19 μM (in U2OS) and 16 μM (in MCF-7). It binds to the PAS-B domain of HIF-1α, inhibiting HIF-1 dimerization and transcriptional activity.

• Downregulates the expression of hypoxia response genes, such as VEGF and CAIX.
• Exhibits antitumor activity against HIF-1 associated cancers.

Medchemexpress LLC Cyclo(CLLFVY) | 1446322-73-1 | 99.37% | 738.94 | 10 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 values of 19 μM (in U2OS) and 16 μM (in MCF-7). It binds to the PAS-B domain of HIF-1α, thereby inhibiting HIF-1 dimerization and transcriptional activity. This compound also downregulates the expression of hypoxia response genes, such as VEGF and CAIX, demonstrating antitumor properties against HIF-1 associated cancers.

• Inhibitor for hypoxia inducible factor-1 (HIF-1)
• Binds to the PAS-B domain of HIF-1α
• Inhibits HIF-1 dimerization and transcriptional activity
• Downregulates the expression of hypoxia response genes (e.g., VEGF and CAIX)
• Exhibits antitumor activity against HIF-1 associated cancers

Medchemexpress LLC Cyclo(L-cysteinyl-L-leucyl-L-leucyl-L-phenylalanyl-L-valyl-L-tyrosyl) | 1446322-73-1 | 99.37% | 738.94 | 5 MG

Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More

Cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), demonstrating IC50 values of 19 μM in U2OS cells and 16 μM in MCF-7 cells. This compound functions by binding to the PAS-B domain of HIF-1α, thereby inhibiting HIF-1 dimerization and its transcriptional activity. It effectively downregulates the expression of hypoxia response genes, including VEGF and CAIX, and has shown antitumor effects against HIF-1 associated cancers.

• Inhibitor for hypoxia inducible factor-1 (HIF-1)
• Binds to the PAS-B domain of HIF-1α
• Inhibits HIF-1 dimerization and transcriptional activity
• Downregulates expression of hypoxia response genes (VEGF, CAIX)
• Exhibits antitumor effects against HIF-1 associated cancers
• Appearance: White to off-white solid
• Solubility: 100 mg/mL in DMSO
• Long-term storage: -80°C for powder