Dimethyl Sulfoxide
Apexbio Technology LLC AICAR 10mM (in 1mL DMSO)
A8184 is a small molecule developed primarily as a biomedical research tool It functions through modulation of specific cellular signaling pathways implicated in disease states enabling researchers to probe biological targets and cellular mechanisms By influencing these pathways A8184 provides a methodological approach for dissecting cellular responses and clarifying mechanisms involved in pathological conditions This compound is suited for controlled in vitro studies aimed at elucidating disease pathways and evaluating potential therapeutic avenues in biomedical research contexts
Apexbio Technology LLC EPZ015666 1616391-65-1 10mM (in 1mL DMSO)
EPZ015666 (CAS 1616391-65-1) is a potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) an enzyme implicated in several cellular pathways including tumorigenesis EPZ015666 inhibits PRMT5 with an IC50 of 22 nM and displays a Ki value of approximately 5 nM It exhibits over 20 000-fold selectivity for PRMT5 relative to other protein methyltransferases tested In mantle cell lymphoma (MCL) cell lines treatment with EPZ015666 reduced methylation levels of the PRMT5 substrate SmD3 and exerted concentration-dependent anti-proliferative effects Additionally EPZ015666 demonstrated dose-dependent tumor growth inhibition in mouse xenograft models of MCL highlighting its potential utility as a molecular tool in cancer biology research
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide suitable for HPLC, >=99.7% | 67-68-5 | MFCD00002089 | 20L
Dimethyl sulfoxide suitable for HPLC, >=99.7% | Purity: >=99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 20L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide for molecular biology | 67-68-5 | MFCD00002089 | 1L
Dimethyl sulfoxide for molecular biology | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 1L
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide PCR Reagent | 67-68-5|MFCD00002089 | 1vl
Dimethyl sulfoxide PCR Reagent | Mol Wt: 78.13 | 67-68-5MFCD000020891 | vl
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 6 x 1 L
Dimethyl sulfoxide | Purity: ≥99.5% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 6 x 1 L
Gold Biotechnology Inc DMSO ACS Grade 100 mL
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Apexbio Technology LLC Verapamil HCl 152-11-4 10mM (in 1mL DMSO)
Verapamil HCl (CAS 152-11-4) is a small molecule belonging to the phenylalkylamine class characterized by selective inhibition of L-type calcium channels By blocking calcium influx through voltage-dependent calcium channels verapamil modulates intracellular calcium signaling affecting smooth muscle contraction cardiac electrophysiology and neurotransmitter release It is frequently utilized in research to investigate calcium channel-related physiological processes cardiovascular function and cellular signaling mechanisms
Apexbio Technology LLC Staurosporine 62996-74-1 10mM (in 1mL DMSO)
Staurosporine is an alkaloid compound originally isolated from the bacterium Streptomyces staurospores and functions as a broad-spectrum inhibitor of serine/threonine protein kinases It potently inhibits multiple kinases including protein kinase C (PKC) protein kinase A (PKA) epidermal growth factor receptor kinase (EGF-R kinase) calmodulin-dependent protein kinase II (CaMKII) phosphorylase kinase and ribosomal protein S6 kinase Its activity against PKC exhibits an IC50 value of approximately 2 7 nM In biomedical research staurosporine is commonly employed to induce apoptosis in mammalian cancer cell lines and to investigate the roles and signaling pathways of protein kinases
Apexbio Technology LLC Baricitinib (LY3009104, INCB028050) 1187594-09-7 10mM (in 1mL DMSO)
Baricitinib (LY3009104 INCB028050 CAS 1187594-09-7) is an orally bioavailable ATP-competitive inhibitor targeting Janus kinases JAK1 and JAK2 It also exhibits moderate inhibition of TYK2 and weaker inhibition against JAK3 In biochemical assays baricitinib inhibits JAK1 and JAK2 with IC50 values of 5 9 nM and 5 7 nM respectively At concentrations below 50 nM baricitinib suppresses intracellular signaling mediated by several pro-inflammatory cytokines notably IL-6 and IL-23 Due to its mechanistic profile baricitinib is actively explored in inflammatory disease research such as rheumatoid arthritis
Apexbio Technology LLC Verteporfin 129497-78-5 10mM (in 1mL DMSO)
Verteporfin (CAS 129497-78-5) is a porphyrin-derived small molecule used as a photosensitizer in photodynamic therapy (PDT) Upon photoactivation verteporfin induces targeted vascular endothelial cytotoxicity through intravascular damage and thrombosis formation leading to selective vessel closure Experimental studies indicate verteporfin treatment triggers DNA fragmentation and enhances apoptotic events in vitro displaying potent cytotoxicity against HL-60 cells at concentrations around 100 ng/mL Independently of photoactivation verteporfin also directly modifies and inhibits the autophagy adaptor protein p62 impacting its binding to polyubiquitinated substrates Verteporfin is relevant to biomedical research involving PDT mechanisms autophagy pathways and angiogenesis
Apexbio Technology LLC BPTES 314045-39-1 10mM (in 1mL DMSO)
BPTES (CAS 314045-39-1) is a selective inhibitor of kidney-type glutaminase (GLS) an enzyme responsible for converting glutamine to glutamate and ammonia It exhibits inhibitory activity against GLS with a reported Ki of approximately 3 M GLS-mediated glutamine metabolism is particularly essential in proliferating and malignant cells BPTES reduces glutamine-to-glutamate conversion in tumor cells diminishing the transamination of pyruvate to alanine as observed in decreased alanine-to-pyruvate ratios in animal models In vitro BPTES inhibits growth by approximately 50% of IDH1-mutant AML cells at 20 M concentration but does not significantly affect wild-type AML cells highlighting its relevance for cancer metabolism research