Dimethyl Sulfoxide
Selleck Chemical LLC GSK2256098 10mM 1mL in DMSOPurity 99.82
GSK2256098 10mM 1mL in DMSOPurity 99.82
Apexbio Technology LLC (S)-(+)-Ibuprofen(Synonyms: Dexibuprofen, (S)-Ibuprofen, (S)-(+)-2-(4-Isobutylphenyl)propionic acid), 10mM (in 1mL DMSO), CAS: 51146-56-6.
(S)-( )-Ibuprofen (CAS 51146-56-6) is the pharmacologically active enantiomer of the racemic nonsteroidal anti-inflammatory drug (NSAID) ibuprofen Unlike its R(-)-counterpart the S( )-form selectively inhibits cyclooxygenase (COX) enzymes thereby suppressing prostaglandin synthesis at concentrations relevant to clinical settings Due to this stereoselectivity (S)-( )-ibuprofen is widely utilized in biomedical research investigating pain inflammation pathways COX enzyme activity and related drug-target interactions
Apexbio Technology LLC Ornidazole 16773-42-5 10mM (in 1mL DMSO)
Ornidazole a 5-nitroimidazole derivative exhibits antibacterial and antiprotozoal activities by interfering with DNA synthesis in anaerobic microorganisms through the reduction of its nitro group forming cytotoxic intermediates In experimental assays Ornidazole demonstrates inhibitory activity against diverse anaerobic bacterial strains including Bacteroides and Clostridium species and protozoan pathogens such as Giardia lamblia and Trichomonas vaginalis typically showing IC50 values ranging from micromolar to low millimolar concentrations This compound is widely utilized in microbiology and infectious disease research to elucidate anaerobic microbial drug sensitivity pathogen resistance mechanisms and protozoan infection biology
Apexbio Technology LLC NVP-AEW541 475489-16-8 10mM (in 1mL DMSO)
NVP-AEW541 (CAS 475489-16-8) is a selective small-molecule inhibitor targeting the insulin-like growth factor-I receptor (IGF-IR) kinase activity Structurally classified as a pyrrolo[2 3-d]pyrimidine derivative NVP-AEW541 effectively inhibits IGF-IR autophosphorylation disrupting downstream IGF-IR mediated signaling cascades It exhibits an IC50 of approximately 0 086 M against IGF-IR kinase In vitro research has demonstrated that treatment of ECC-1 and USPC-1 endometrial cancer cell lines with NVP-AEW541 leads to altered cell cycle progression induction of apoptosis and suppression of proliferation Furthermore NVP-AEW541 has been shown to enhance radiosensitivity specifically in PTEN wild-type cancer cell lines indicating its potential utility as an adjunctive therapeutic agent in oncology research
![Apexbio Technology LLC Scriptaid(Synonyms: Scriptaid, HDAC inhibitor Scriptaid, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide), 10mM (in 1mL DMSO), CAS: 287383-59-9.](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000060690.PNG-250.jpg)
Apexbio Technology LLC Scriptaid(Synonyms: Scriptaid, HDAC inhibitor Scriptaid, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide), 10mM (in 1mL DMSO), CAS: 287383-59-9.
Scriptaid (CAS 287383-59-9) is a small-molecule histone deacetylase (HDAC) inhibitor originally identified through high-throughput transcriptional screening It specifically targets class I HDAC isoforms inhibiting HDAC1/HDAC3 and HDAC8 with IC50 values of approximately 0 6 M and 1 M respectively Structurally related to other hydroxamic acid-containing HDAC inhibitors such as TSA Scriptaid consists of a hydroxamic acid moiety a connecting linker and an aromatic cap group In glioblastoma (GBM) research Scriptaid shows promise by inducing apoptosis in glioma cells highlighting its potential utility for oncology-focused investigations
Apexbio Technology LLC Romidepsin (FK228, depsipeptide) 128517-07-7 10mM (in 1mL DMSO)
Romidepsin (FK228 depsipeptide CAS 128517-07-7) is a small-molecule inhibitor targeting histone deacetylases (HDACs) Initially isolated from Chromobacterium violaceum romidepsin preferentially inhibits class I enzymes HDAC1 and HDAC2 over class II HDAC4 and HDAC6 Inhibition of HDAC activity by romidepsin results in increased histone acetylation promoting transcriptional activation of tumor suppressor genes Mechanistically this compound can trigger cellular differentiation cell-cycle arrest apoptosis and altered gene expression in various malignancies Romidepsin serves as a research tool to investigate epigenetic regulation and has notable anticancer properties in cell models such as neuroblastoma and cutaneous T-cell lymphoma
Medchemexpress LLC Cimetidine sulfoxide | 54237-72-8 | 97.0% | C10H16N6OS | 10MG
Cimetidine sulfoxide is the sulfoxide metabolite of cimetidine provided for research and analytical applications (CAS 54237-72-8). Supplied as a research-grade solid, it is used as a reference standard in studies of histamine H2-receptor antagonists, drug metabolism, and analytical method development.
- High-purity reference standard suitable for analytical assays.
- Useful for metabolic and pharmacokinetic studies.
- Available in small milligram pack sizes for research use.
- Documentation available: COA, SDS, and handling instructions.
- Stable solid form for storage and long-term use.
Apexbio Technology LLC TG003 300801-52-9 10mM (in 1mL DMSO)
TG003 (CAS 300801-52-9) is a selective inhibitor targeting the Cdc2-like kinase (Clk) family and casein kinase 1 (CK1) Specifically it demonstrates notable potency against mClk1 mClk2 and mClk4 with IC50 values of approximately 20 nM 200 nM and 15 nM respectively TG003 competitively binds with ATP at Clk1 modulating Clk-mediated phosphorylation of serine/arginine-rich (SR) proteins involved in alternative mRNA splicing Studies using HeLa cellular extracts and animal models have shown that TG003 alters splice site selection and pre-mRNA processing suggesting potential utility for investigating RNA splicing regulatory mechanisms
Apexbio Technology LLC Trametinib DMSO solvate 1187431-43-1 10mM (in 1mL DMSO)
Trametinib DMSO solvate (CAS 1187431-43-1) is a potent allosteric inhibitor of MEK1 and MEK2 that acts through an ATP-noncompetitive mechanism In preclinical models it has demonstrated broad antitumor activity notably in colorectal cancer cell lines such as HT-29 and COLO205 Trametinib induces the expression of p15 and p27 suppresses cyclin D1 promotes RB dephosphorylation and G1 cell cycle arrest and reduces thymidylate synthase expression Furthermore it inhibits ERK1/2 phosphorylation leading to growth suppression in B-RAF mutant tumor cells Trametinib serves as a valuable tool for studying MAPK pathway signaling and targeted cancer therapeutics
Apexbio Technology LLC Cediranib (AZD217) 288383-20-0 10mM (in 1mL DMSO)
Cediranib (AZD2171 CAS 288383-20-0) is an orally bioavailable small molecule inhibitor targeting the kinase insert domain receptor (KDR VEGFR-2) with potent inhibition observed in recombinant assays (IC50 1 nM) Additionally cediranib suppresses related vascular endothelial growth factor receptors VEGFR-1 (Flt-1 IC50 5 nM) and VEGFR-3 (Flt-4 IC50 3 nM) It also blocks select platelet-derived growth factor receptors notably c-Kit PDGFR PDGFR and CSF-1R at nanomolar to sub-micromolar concentrations indicating multiple-kinase targeting capability Cediranib serves as a valuable research compound for studying tumor angiogenesis and kinase-driven oncogenic pathways
Apexbio Technology LLC BKM120 944396-07-0 10mM (in 1mL DMSO)
BKM120 (CAS 944396-07-0) is a potent orally bioavailable inhibitor of class I phosphatidylinositol 3-kinases (PI3Ks) specifically targeting the isoforms p110 p110 p110 and p110 with IC50 values of 52 nM 166 nM 262 nM and 116 nM respectively By blocking PI3K activity this molecule suppresses downstream phosphorylation of AKT an important mediator within the PI3K-AKT-mTOR signaling cascade implicated in tumor growth and survival Preclinical studies demonstrate that BKM120 restricts tumor cell proliferation promotes cell cycle arrest at G1 phase and induces apoptosis particularly noted in PTEN-deficient cancer models Thus BKM120 serves as a useful tool for studying PI3K pathway-dependent cancers
Apexbio Technology LLC Crenolanib (CP-868596)(Synonyms: CP-868596, Crenolanib besylate, AR-868596, PDGFR inhibitor CP-868596, PDGFR-beta inhibitor CP-868596), 10mM (in 1mL DMSO), CAS: 670220-88-9.
Crenolanib (CP-868596 CAS 670220-88-9) is a selective inhibitor targeting receptor tyrosine kinases PDGFR PDGFR and FLT3 exhibiting Kd values of 3 2 nM 2 1 nM and 0 74 nM respectively It notably suppresses the FLT3 autophosphorylation and proliferation mediated via PDGFR mutations that confer resistance to imatinib such as D842V (IC50 10 nM) but does not inhibit the V561D mutant Additionally crenolanib reduces kinase activity of the FIP1L1-PDGFRA fusion protein (IC50 1 nM) and proliferation in EOL-1 cells It serves as a research tool for kinase-driven malignancies particularly those resistant to other kinase inhibitors
Gold Biotechnology Inc Sterile Filtered DMSO
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Apexbio Technology LLC Quizartinib (AC220) 950769-58-1 10mM (in 1mL DMSO)
Quizartinib (AC220) is a second-generation small molecule inhibitor specifically targeting FMS-like tyrosine kinase 3 (FLT3) It exhibits potent inhibitory activity against FLT3 kinases harboring internal tandem duplication (ITD) and wild-type forms with reported IC50 values around 1 1 nM and 4 2 nM respectively Quizartinib demonstrates selectivity for FLT3 with minimal inhibition toward other kinases such as KIT PDGFR / RET and CSF-1R In cell-based assays using MV4-11 AML cell lines that express FLT3-ITD quizartinib reduces FLT3 phosphorylation thus inhibiting downstream signaling pathways involved in tumor cell proliferation and survival Quizartinib is utilized primarily in leukemia research to examine FLT3 signaling dependency and resistance mechanisms providing a useful tool for investigating molecular pathways and therapeutic strategies in acute myeloid leukemia (AML)
Apexbio Technology LLC Ki16198 355025-13-7 10mM (in 1mL DMSO)
Ki16198 (CAS 355025-13-7) is the methyl ester derivative of Ki16425 and functions as an antagonist of lysophosphatidic acid (LPA) receptors preferentially inhibiting LPA1 and LPA3 receptor subtypes Ki16198 reduces receptor-mediated inositol phosphate production with Ki values of 0 34 M (LPA1) and 0 93 M (LPA3) showing minimal inhibition of LPA2 and no significant activity against LPA4 6 In vitro Ki16198 attenuates LPA-induced proliferation migration invasion and proMMP-9 expression in cancer cells In vivo studies report suppression of pancreatic tumor growth metastasis and ascites formation highlighting its utility in investigating LPA-related cancer progression pathways