Dimethyl Sulfoxide
Apexbio Technology LLC LDN193189 Hydrochloride 1062368-62-0 10mM (in 1mL DMSO)
LDN193189 Hydrochloride is a selective pharmacological inhibitor targeting BMP type I receptor kinases specifically activin receptor-like kinase 2 (ALK2) and ALK3 The compound acts by blocking receptor-mediated activation of Smad-dependent signaling pathways (Smad1/5/8 phosphorylation) as well as mitigating associated non-Smad signaling including phosphorylation of Akt and p38 Commonly utilized in biomedical research involving cellular differentiation epithelial barrier integrity and heterotopic ossification LDN193189 has shown the capacity to modulate BMP-induced phenotypic changes in various cell lines such as C2C12 myoblasts and bronchial epithelial cells and to influence related in vivo processes
Apexbio Technology LLC Caspofungin(Synonyms: Cancidas, Caspofungin acetate, MK-0991, L-743872), 10mM (in 1mL DMSO), CAS: 162808-62-0.
Caspofungin (CAS 162808-62-0) is a small-molecule inhibitor of -1 3-glucan synthase an enzyme essential for the biosynthesis of -(1 3)-D-glucan a fundamental cell wall component in pathogenic fungi such as Candida albicans Caspofungin selectively inhibits -1 3-glucan synthase activity with a reported IC50 of approximately 0 6 nmol/L in membrane preparations of C albicans Caspofungin demonstrates potent antifungal activity against various Candida isolates including azole-resistant strains (MIC90 0 5 g/mL) and shows prolonged post-antifungal effects lasting 6 8 hours It is widely utilized in biomedical research involving fungal infections and antifungal therapeutics
Apexbio Technology LLC VX-661(Synonyms: Tezacaftor, VX661, VX-661, VX 661), 10mM (in 1mL DMSO), CAS: 1152311-62-0.
VX-661 (CAS 1152311-62-0) is a small-molecule CFTR corrector developed by Vertex Pharmaceuticals designed to restore trafficking and enhance cellular surface expression of the mutated F508del-CFTR protein By facilitating proper folding and transport of this commonly mutated cystic fibrosis transmembrane conductance regulator (CFTR) VX-661 increases CFTR-mediated chloride channel activity in vitro Preclinical and clinical research have explored VX-661 alone and in combination with ivacaftor demonstrating enhanced F508del-CFTR functionality and providing a promising strategy for addressing cystic fibrosis caused by the F508del mutation
Apexbio Technology LLC AST-1306 897383-62-9 10mM (in 1mL DMSO)
AST-1306 (CAS 897383-62-9) is an inhibitor of epidermal growth factor receptor (EGFR) and HER2 receptor tyrosine kinases In biochemical assays AST-1306 inhibits EGFR and HER2 kinase activity with IC50 values of 0 5 nM and 3 nM respectively It also demonstrates inhibitory activity against EGFR mutations such as T790M/L858R reducing receptor phosphorylation and downstream signaling in both cell-free and cellular systems In various animal tumor models including ErbB2-overexpressing and SK-OV-3 xenografts AST-1306 suppresses tumor growth and signaling pathways supporting its use in EGFR- and HER2-related oncology research