Dimethyl Sulfoxide
Apexbio Technology LLC BIBR 1532 321674-73-1 10mM (in 1mL DMSO)
BIBR 1532 (CAS 321674-73-1) is a selective non-nucleosidic inhibitor of telomerase exhibiting an IC50 of approximately 93 nM It targets human telomerase reverse transcriptase (hTERT) reducing enzymatic activity and causing telomere shortening Mechanistically BIBR 1532 suppresses cancer cell proliferation and induces apoptosis by modulating c-Myc and hTERT transcription elevating pro-apoptotic signaling through p73 Bax/Bcl-2 ratio and caspase-3 activation It has demonstrated inhibitory effects on proliferation and survival in several leukemia cell lines including pre-B acute lymphoblastic leukemia and acute promyelocytic leukemia (NB4) highlighting its utility in oncology research
Apexbio Technology LLC CFI-400945 1338806-73-7 10mM (in 1mL DMSO)
CFI-400945 (CAS 1338806-73-7) is an orally bioavailable inhibitor specifically targeting polo-like kinase 4 (PLK4) a member of the polo-like kinase family involved in centriole duplication and cell cycle control By competitively inhibiting ATP binding to PLK4 CFI-400945 potently suppresses PLK4 catalytic activity (IC50 2 8 nM) and blocks PLK4 autophosphorylation in cellular assays (EC50 12 3 nM) The compound exhibits high selectivity against other polo-like kinases and demonstrates antiproliferative activity in various cancer cell lines Thus CFI-400945 is applied in cancer biology research particularly for studying centrosome regulation and tumor growth inhibition
Apexbio Technology LLC KPT-185 1333151-73-7 10mM (in 1mL DMSO)
KPT-185 (CAS 1333151-73-7) is an irreversible selective inhibitor of chromosome region maintenance 1 (CRM1) a nuclear export receptor essential for nuclear-cytoplasmic transport KPT-185 binds covalently at Cys528 of CRM1 thereby inhibiting CRM1-mediated nuclear export of tumor suppressor proteins Studies demonstrate that KPT-185 impairs proliferation and colony formation in acute myeloid leukemia (AML) cell lines exhibiting IC50 values ranging from 100 500 nM inducing G1 cell cycle arrest apoptosis and differentiation of AML blasts Additionally KPT-185 reduces growth and promotes apoptosis in pancreatic cancer models (Colo-357 HPAC BxPC-3) highlighting its potential in cancer research