Tetrahydrofuran
Medchemexpress LLC Mpt0b392 | 1346169-92-3 | 99.6% | 404.44 | C19H20N2O6S | 5 MG
This research compound is a quinoline-derived microtubule-depolymerizing agent that activates c-Jun N-terminal kinase (JNK), induces mitotic arrest, and promotes apoptosis. Intended for preclinical in-vitro and in-vivo research.
- High purity (99.6%) for reproducible results.
- Mechanism: microtubule depolymerization and JNK activation.
- Suitable for in vitro and in vivo preclinical studies.
- Soluble in DMSO; sonication recommended for full dissolution.
- Powder stable at -20°C; follow solvent storage recommendations.
Medchemexpress LLC PF-00446687 free bas 100mg | 862281-92-3 | 100MG
PF-00446687 is a potent selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 1 nM[1 Pf-446687 is brain penetrant[2
Medchemexpress LLC Kinase, Natto fermentation | 133876-92-3 | 27728 Da | 10 MG
Kinase, Natto fermentation is a potent fibrinolytic enzyme that breaks down blood clots by directly hydrolyzing fibrin and plasmin substrate. It is primarily used for cardiovascular disease research.
- Breaks down blood clots by directly hydrolyzing fibrin and plasmin substrate.
- Dissolves 94% of blood clots within ten minutes in vitro.
- Degrades fibrin clots after two hours of incubation in vitro.
- Exhibits fibrinolytic activity and dissolves blood clots in vivo.
- Stable in neutral or alkaline environments (pH 7.0-12.0).
- Stability improved when mixed with boiled rice extract, broth, serum protein, or gastric juice protein.
- Retains enzyme activity under acidic conditions with stabilizing agents.
- Better stability below 37°C.
- Retains 95% of original activity after 5 freeze-thaw cycles.
Medchemexpress LLC MPT0B392 | 1346169-92-3 | MFCD32174244 | 99.6% | 404.44 | C19H20N2O6S | 50 MG
MPT0B392 is an orally active quinoline-derived microtubule-depolymerizing agent that inhibits tubulin polymerization, activates c-Jun N-terminal kinase (JNK), and induces apoptosis. It is used in cellular assays and preclinical models to study microtubule dynamics and apoptosis signaling pathways.
- Inhibits tubulin polymerization and induces mitotic arrest.
- Activates c-Jun N-terminal kinase (JNK) and promotes apoptosis.
- High purity (99.6%) for reliable experimental results.
- Soluble in DMSO (≈100 mg/mL) for convenient formulation.
- Solid, light yellow appearance for easy inspection.
- Stable as powder at -20°C for up to 3 years.
Medchemexpress LLC MPT0B392 | 1346169-92-3 | 99.6% | 404.44 g/mol | C19H20N2O6S | 100 MG
MPT0B392 is an orally active quinoline-derived microtubule-depolymerizing agent that activates c-Jun N-terminal kinase (JNK) and induces apoptosis. It inhibits tubulin polymerization and causes mitotic arrest, making it useful in cell biology and oncology research investigating microtubule dynamics and drug resistance mechanisms.
- High purity (≈99.6%) suitable for research assays.
- Solid powder, light yellow to yellow appearance.
- Well-characterized molecular properties (C19H20N2O6S, 404.44 g/mol).
- Documented storage stability in powder and solution.
- Biological activity: tubulin depolymerizer, JNK activator, apoptosis inducer.
- Includes CAS number for unambiguous identification.
Medchemexpress LLC Kinase, Natto fermentation | 133876-92-3 | 27728 Da | 50 MG
Kinase, Natto fermentation is a potent fibrinolytic enzyme that can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. It can be used for the research of cardiovascular diseases.
- Breaks down blood clots
- Molecular weight: 27728 Da
- Relatively stable in neutral or alkaline environment (pH 7.0-12.0)
- Sensitive to high temperature, with better stability below 37°C
- Retains 95% activity after 5 freeze-thaw cycles
- Exhibits fibrinolytic activity and dissolves blood clots in vivo
Medchemexpress LLC Mpt0b392 | 1346169-92-3 | 99.6% | 404.44 g/mol | C19H20N2O6S | 10 MG
MPT0B392 is a research-grade microtubule-depolymerizing agent for preclinical studies of tubulin dynamics and cancer drug resistance. It is an orally active quinoline derivative that inhibits tubulin polymerization, activates c-Jun N-terminal kinase (JNK), induces mitotic arrest, and promotes apoptosis. Supplied as a solid or as a 10 mM solution in DMSO for in vitro and in vivo research use.
- Novel microtubule-depolymerizing mechanism supporting tubulin studies.
- Induces JNK activation and mitotic arrest for apoptosis research.
- Available as solid or 10 mM solution in DMSO for flexible dosing.
- High listed purity (99.63%) suitable for biochemical assays.
- Documented molecular weight and formula to aid experimental planning.
Medchemexpress LLC PF-00446687 free base | 862281-92-3 | 98.0% | 470.59 g/mol | C28H36F2N2O2 | 50 MG
PF-00446687 free base is a non-peptide, brain-penetrant small-molecule agonist of the melanocortin-4 receptor (MC4R) used in research on melanocortin signaling and central nervous system pharmacology. It is supplied as a powder for in vitro and in vivo studies and demonstrates low-nanomolar potency and selectivity.
- Selective melanocortin-4 receptor agonist with EC50 12 ± 1 nM.
- Binding affinity (Ki) approximately 27 ± 4 nM.
- Brain-penetrant, suitable for central nervous system studies.
- Provided as a powder with solubility in DMSO 62.5 mg/mL (ultrasonic recommended).
- Molecular formula C28H36F2N2O2 and molecular weight 470.59 g/mol.
- High purity by HPLC (≈98.0% per COA).
- Storage: powder -20°C (long-term) or 4°C (short-term).
Medchemexpress LLC 5-amino-6-methoxy-2-(3',4',5'-trimethoxyphenylsulfonyl)quinoline | 1346169-92-3 | MFCD32174244 | 99.6% | 404.44 | C19H20N2O6S | 25 MG
A quinoline-derived research compound that acts as a microtubule-depolymerizing agent. It inhibits tubulin polymerization, induces mitotic arrest and c-Jun N-terminal kinase-mediated apoptosis, and can sensitize resistant cancer cell lines to mTOR pathway inhibitors. Supplied as a solid for laboratory research use.
- Microtubule-depolymerizing activity observed in cell assays.
- Induces mitotic arrest and JNK-mediated apoptosis.
- High purity (~99.6%) for reproducible results.
- Molecular weight 404.44; formula C19H20N2O6S.
- Soluble in DMSO at 100 mg/mL; ultrasonic agitation recommended.
- Available in small sample sizes (5 mg-100 mg); powder storage at -20°C.