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Organic compounds with acidic properties, organic acids are generally weak acids incapable of complete dissociation in water. Available in a range of chemical compositions and acid strengths, they can be used for various industrial and everyday applications.
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ω-Agatoxin IVA TFA is a potent and selective blocker of P/Q type Ca2+ (Cav2.1) channels. It exhibits IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels. The compound inhibits glutamate exocytosis and calcium influx, as well as the release of serotonin and norepinephrine, when elicited by high potassium. It does not affect L-type or N-type calcium channels.
Potent and selective P/Q type Ca2+ (Cav2.1) channel blocker.
IC50s of 2 nM for P-type and 90 nM for Q-type Ca2+ channels.
Inhibits glutamate exocytosis and calcium influx.
Blocks high potassium-induced release of serotonin and norepinephrine.
Has no effect on L-type or N-type calcium channels.
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