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Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
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Tiotropium Bromide (CAS 136310-93-5) is a potent antagonist of muscarinic acetylcholine receptors (mAChRs) By competitively inhibiting acetylcholine binding at these receptors it prevents receptor activation and subsequent signaling cascades leading to decreased neuronal transmission and smooth muscle relaxation As a long-acting anticholinergic bronchodilator with activity lasting approximately 24 hours Tiotropium Bromide is widely studied in managing chronic obstructive pulmonary disease (COPD) including cases complicated by chronic heart failure
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate sodium is a phosphatidic acid sodium salt supplied as a white to off-white solid for biochemical research. It is commonly used to probe membrane properties and cell signaling pathways and is provided at high purity for laboratory use.
High purity: 99.0%.
Monosodium salt form for improved aqueous handling.
Solid, white to off-white appearance.
Suitable for membrane and cell signaling studies.
Available in multiple small-scale sizes for research use.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism
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