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Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
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Des-octanoyl-Ghrelin (rat) is a desacylated peptide derivative lacking the octanoyl modification present in ghrelin resulting in decreased affinity for the growth hormone secretagogue receptor type 1a (GHS-R1a) It modulates metabolic processes such as energy homeostasis glucose regulation insulin sensitivity and lipid metabolism primarily through alternative receptor-mediated pathways Des-octanoyl-Ghrelin (rat) exerts its biological activity via modulation of endocrine regulation and inflammatory responses Based on these pharmacological properties Des-octanoyl-Ghrelin (rat) holds research potential in studies of appetite control metabolic disorders and elucidating signaling pathways linked to metabolism-related diseases
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Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism
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N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is a compound designed for the synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. It serves as a valuable tool for investigating enzyme-catalyzed cleavage processes in DNA.
Used for synthesis of oligodeoxynucleotides
Contains a 3'-S-phosphorothiolate (3'-PS) linkage
Useful tool for probing enzyme-catalyzed cleavage processes in DNA
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4-(2-Bromoacetyl)benzonitrile, also known as 4-Cyanophenacyl bromide, is a compound used in the synthesis of STA-5312, a potent and orally active microtubule inhibitor. This product is intended for research use only.
Can be utilized in the synthesis of STA-5312.
Appears as an off-white to yellow solid.
Store at 4°C, protected from light.
In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light.
Soluble in DMSO at 100 mg/mL.
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N4-Benzoyl-2 -O-methylcytidine is a natural cytidine nucleoside analog Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities[1][2]
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