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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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LMP2A (426-434) is an HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope of Epstein-Barr virus (EBV) latent membrane protein 2A (LMP2A). It can trigger an immune response in individuals expressing various HLA-A*02 subtypes and induces a strong IFN-γ secretion response, leading to a high proportion of CD8+ IFN-γ+ T cells. It induces specific CTLs that effectively kill target cells expressing LMP2A.
Suitable for studying EBV-related malignant tumors, such as Hodgkin's disease and nasopharyngeal carcinoma.
Induces IFN-γ secreting cells at a frequency of 80.6 SFC/5x10⁴ CD8+ T cells (at 20 μg/mL for 24 h).
Significantly increases the proportion of CD8+IFN-γ+ cells after two weeks of stimulation (at 20 μg/mL).
Specific CTLs effectively kill peptide-pulsed T2 cells and 293T-LMP2A cells (at 20 μg/mL for 4 h).
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A perfluoroalkyl substance; chronic topical administration on the EAr increases liver and kidney weight in mice at 25 µl of a 3.75-15% v/v on the EAr; induces multifocal hepatocyte necrosis and centrilobular hepatocyte hypertrophy at 7.5% v/v; increases serum cholesterol and ALP levels at 15% v/v; decreases serum urea nitrogen levels; has been found in marine life and as a contaminant in surface water
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N-Boc-8-amino-octanoic acid is a Boc-protected amino acid with an eight-carbon aliphatic spacer and a terminal carboxylic acid. It is used as a flexible linker in PROTAC and peptide synthesis; the carboxylic acid can be coupled to amines to form amide bonds, and the Boc protecting group can be removed under mild acidic conditions to reveal the free amine.
Boc-protected amino acid suitable for peptide and PROTAC linker synthesis.