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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
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BQR-695 is a PI4KIIIβ inhibitor, active against both human and *Plasmodium* variants of PI4KIIIβ. It effectively inhibits PI4KIIIβ function, leading to depletion of intracellular PI4P, and shows no toxicity against mature red blood cells. It induces schizont-stage arrest and exhibits cross-resistance with imidazopyrazine-resistant lines.
Inhibits human PI4KIIIβ with an IC50 of 80 nM
Inhibits *Plasmodium* PI4KIIIβ with an IC50 of 3.5 nM
Causes GFP-PHOsh2 to redistribute to parasite plasma membrane
No toxicity against mature red blood cells
Induces schizont-stage arrest
Exhibits cross-resistance with imidazopyrazine-resistant lines
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N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide (Calcium ionophore II) is a lipophilic ionophore that can be used in preparing calcium ion-selective electrodes. Calcium ion-selective electrodes can be used to measure intracellular free calcium.
Lipophilic ionophore
Used in preparing calcium ion-selective electrodes
Enables measurement of intracellular free calcium
For research use only
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