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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
An esterified form of 12-oxo stearic acid; has been found in esterified L. chinensis and L. decipiens pulp oils and serves as a measure of 12-oxo stearic acid content
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Octadecane-1-thiol-d37 is a deuterium labeled version of Octadecane-1-thiol. It is intended for research use only and not for sale to patients. Stable heavy isotopes like deuterium have been incorporated into drug molecules for use as tracers in drug development, and deuteration may impact the pharmacokinetic and metabolic profiles of drugs.
Used as a tracer.
Can be utilized as an internal standard for quantitative analysis through NMR, GC-MS, or LC-MS.
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SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. It exhibits anti-COVID-19 activity by targeting Mpro (IC50 of 30 nM).
Orally active inhibitor of IL-1β converting enzyme and caspase-1
Exhibits anti-COVID-19 activity
Potently reduces carrageenin-induced paw oedema
Displays analgesic activity in the Randall-Selitto yeast-inflamed paw pressure test
For research use only
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Dynole 2-24 is an indole-based dynamin GTPase inhibitor with an IC₅₀ of 0.56 μM for dynamin I. This compound is non-toxic and demonstrates increased potency against dynamin I and II both in vitro and within cells, with an IC₅₀ (CME) of 1.9 μM. It exhibits a 4.4-fold selectivity for dynamin I. Dynole 2-24 acts as an active in-cell inhibitor of clathrin-mediated endocytosis (CME).
Indole-based dynamin GTPase inhibitor.
IC₅₀ of 0.56 μM for dynamin I.
Nontoxic.
Increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM).
Shows 4.4-fold selectivity for dynamin I.
Active in-cell inhibitor of clathrin-mediated endocytosis.
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